Aminopyrine

Description

What is Aminopyrine?

Antipyretic and analgesic for fever, headache, joint pain, neuralgia, dysmenorrhea and active rheumatism. Aminopyrine is a pyrazolone non-steroidal anti-inflammatory drug with strong antipyretic, analgesic, anti-inflammatory and anti-rheumatic actions.

But due to serious adverse reactions, such as agranulocytosis, aplastic anemia and so on. Therefore, the clinical application has been decreasing day by day, and gradually tend to be eliminated. Aminopyrine can also be used as an analytical reagent for the determination of antimony, bismuth, bromine, cadmium, chlorine, cobalt, ketone, cyanide, gold, ferric acid, lead, nickel, nitric acid, nitrite, osmium, nitrogen oxides, Palladium, platinum, silver and zinc.

4-DiMethylaMino Antipyrine Basic information

Product Name:	4-DiMethylaMino Antipyrine
Synonyms:	2-dihydro-4-(N.,N-dimethylamino-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;4-Dimethylamino-2,3-dimethyl-1-phenyl pyrazol－1－one, 97%;4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Aminopyrine;Amidozon;Aminofebrin;Aminopyrazolin;4-(Dimethylamino)antipyrine, 98+%;4-Dimethylaminoantipyrine,97%
CAS:	58-15-1
MF:	C13H17N3O
MW:	231.29
EINECS:	200-365-8
Product Categories:	Miscellaneous; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals
Mol File:	58-15-1.mol

Aminopyrazolin Chemical Structure

4-DiMethylaMino Antipyrine

Aminofebrin Chemical Properties

Melting point	107-109 °C(lit.)
Boiling point	373.38°C (rough estimate)
density	1.0744 (rough estimate)
refractive index	1.6140 (estimate)
storage temp.	Refrigerator
pka	pKa 5.0 (Uncertain)
form	Crystalline Powder, Crystals and/or Chunks
color	Off-white to brownish
Water Solubility	5.55 g/100 mL
Sensitive	Air & Light Sensitive
Merck	14,474
Stability:	Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive. Degrades under the action of mild oxidizing agents in the presence of moisture or water.
InChIKey	RMMXTBMQSGEXHJ-UHFFFAOYSA-N
CAS DataBase Reference	58-15-1(CAS DataBase Reference)
NIST Chemistry Reference	Aminopyrine(58-15-1)
EPA Substance Registry System	Aminopyrine (58-15-1)

Amidozon Usage And Synthesis

Aminopyrine tablets is a pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, an environmental contaminant and a xenobiotic. It is a tertiary amino compound and a pyrazolone.

Chemical Properties	white crystalline powder
Uses	Antipyretic; analgesic.
Uses	Antipyretic;ACTH secretor
Definition	ChEBI: A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properies.