ZANAMIVIR HYDRATE

Description

ZANAMIVIR HYDRATE is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles. It was launched as Relenza in Australia for treatment of human influenza A and B virus infections.

Human studies have shown that ZANAMIVIR HYDRATE is effectivewhen administered before or after exposure to the influenzavirus. If administered before exposure to the virus, the drugreduced viral propagation, infectivity, and disease symptoms.If administered after exposure, the drug reduces propagation,viral titer, and illness.

Zanamivir Hydrate 98 Basic information

Product Name:	ZANAMIVIR HYDRATE
Synonyms:	ZANAMIVIR; 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid;
CAS:	139110-80-8
MF:	C12H20N4O7
MW:	332.31
EINECS:	691-117-1
Product Categories:	Inhibitors; Anti-virals; Anti-viral Compounds; Intermediates & Fine Chemicals; Pharmaceuticals

Zanamivir Hydrate 98 Chemical Structure

ZANAMIVIR HYDRATE

Zanamivir Hydrate Chemical Properties

Melting point	2560C (dec.)
alpha	D20 +40.9° (c = 0.9 in water)
density	1.75±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	H2O: soluble10mg/mL, clear
form	powder
pka	3.82±0.70(Predicted)
color	white to beige
optical activity	[α]/D +30 to +40°, c = 1 in H2O
InChIKey	ARAIBEBZBOPLMB-UFGQHTETSA-N

Zanamivir Hydrate Usage And Synthesis

Chemical Properties	Colorless Crystalline Solid
Uses	Influenza viral neuraminidase inhibitor; structural analog of the sialic acid. Antiviral
Uses	antineoplastic, anti-metabolite
Therapeutic Function	Antiviral
Pharmaceutical Applications	A synthetic neuraminidase inhibitor formulated for administration by inhalation.