Clindamycin Phosphate

Description

Clindamycin Phosphate is the phosphate salt form of clindamycin, a semi-synthetic, chlorinated broad spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin phosphate is used in topical preparations.

Clindamycin phosphate Basic information

Product Name:	Clindamycin phosphate
Synonyms:	(2s-trans)-;2-(dihydrogenphosphate;U-28508E; Clindamycin phosphate BP98,USP25,EP97; Clindaymcin Palmitate hydrochloride USP23; L-threo-.alpha.-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(2S,4R)-1-methyl-4-propyl-2-pyrrolidinylcarbonylamino-1-thio-, 2-(dihydrogen phosphate); CLINDAMYCINPHOSPHATE,CRYSTAL,USP; CLINDAMYCIN PHOSPHATE/ 7-(S)-CHLORO-7-DEOXY-LINCOMYCIN-2-ORGANIC PHOSPHATE
CAS:	24729-96-2
MF:	C18H34ClN2O8PS
MW:	504.96
EINECS:	246-433-0
Product Categories:	API’s; Intermediates & Fine Chemicals; Antibiotics for Research and Experimental Use; Pharmaceuticals
Mol File:	24729-96-2.mol

Clindamycin phosphate Chemical Structure

Clindamycin phosphate

Cleocin t Chemical Properties

Melting point	114 °C
Boiling point	159°C
density	1.41±0.1 g/cm3(Predicted)
refractive index	122 ° (C=1, H2O)
storage temp.	2-8°C
solubility	DMSO: soluble224mg/mL at 25°C
form	solid
pka	pKa 0.964±0.06 (H2O t=21) (Uncertain);6.06 ±0.06 (I=0.008)(H2O t=21) (Uncertain)
Water Solubility	Freely soluble in water
Merck	14,2356
Stability:	Stable, but store cool. Incompatible with strong oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium vitamins.

Cleocin t Usage And Synthesis

Uses

Clindamycin phosphate is used topically alone or in conjunction with benzoyl peroxide in the treatment of inflammatory acne vulgaris. In weighing the potential benefits of topical clindamycin therapy, the possibility of serious adverse GI effects associated with the drug should be considered. Therapy of acne vulgaris must be individualized and frequently modified depending on the types of acne lesions which predominate and the response to therapy. Topical anti-infectives, including clindamycin, generally are effective in the treatment of mild to moderate inflammatory acne. However, use of topical anti-infectives as monotherapy may lead to bacterial resistance; this resistance is associated with decreased clinical efficacy.Topical clindamycin is particularly useful when used with benzoyl peroxide or topical retinoids. Results of clinical studies indicate that combination therapy results in a reduction in total lesion counts of 50-70%.

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

Email us at: info@maxmedchem.com for more details.