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Clindamycin Phosphate (24729-96-2) C18H34ClN2O8PS

  • Chemical Name:Clindamycin phosphate
  • CAS No.:24729-96-2
  • MF: C18H34ClN2O8PS
  • MW:504.96
  • Specification: USP|EP|BP
  • Purity: >95% or As customer requested
  • Solubility:Freely soluble in water
  • Product Categories:Antibiotics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
  • Test method: HPLC

Clindamycin Phosphate is the phosphate salt form of clindamycin, a semi-synthetic, chlorinated broad spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin phosphate is used in topical preparations.(Source: NCI Thesaurus (NCIt))

Clindamycin phosphate Basic information  
Product Name: Clindamycin phosphate
Synonyms: (2s-trans)-;2-(dihydrogenphosphate;U-28508E; Clindamycin phosphate BP98,USP25,EP97; Clindaymcin Palmitate hydrochloride USP23; L-threo-.alpha.-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(2S,4R)-1-methyl-4-propyl-2-pyrrolidinylcarbonylamino-1-thio-, 2-(dihydrogen phosphate); CLINDAMYCINPHOSPHATE,CRYSTAL,USP; CLINDAMYCIN PHOSPHATE/ 7-(S)-CHLORO-7-DEOXY-LINCOMYCIN-2-ORGANIC PHOSPHATE
CAS: 24729-96-2
MF: C18H34ClN2O8PS
MW: 504.96
EINECS: 246-433-0
Product Categories: API's; Intermediates & Fine Chemicals; Antibiotics for Research and Experimental Use; Pharmaceuticals
Mol File: 24729-96-2.mol

Clindamycin phosphate Chemical Structure

Clindamycin phosphate            

Cleocin t Chemical Properties   
Melting point  114 °C
Boiling point  159°C
density  1.41±0.1 g/cm3(Predicted)
refractive index  122 ° (C=1, H2O)
storage temp.  2-8°C
solubility  DMSO: soluble224mg/mL at 25°C
form  solid
pka pKa 0.964±0.06 (H2O t=21) (Uncertain);6.06 ±0.06 (I=0.008)(H2O t=21) (Uncertain)
Water Solubility  Freely soluble in water
Merck  14,2356
Stability: Stable, but store cool. Incompatible with strong oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium vitamins.

Cleocin t Usage And Synthesis


Uses Clindamycin phosphate is used topically alone or in conjunction with benzoyl peroxide in the treatment of inflammatory acne vulgaris. In weighing the potential benefits of topical clindamycin therapy, the possibility of serious adverse GI effects associated with the drug should be considered. Therapy of acne vulgaris must be individualized and frequently modified depending on the types of acne lesions which predominate and the response to therapy. Topical anti-infectives, including clindamycin, generally are effective in the treatment of mild to moderate inflammatory acne. However, use of topical anti-infectives as monotherapy may lead to bacterial resistance; this resistance is associated with decreased clinical efficacy.Topical clindamycin is particularly useful when used with benzoyl peroxide or topical retinoids. Results of clinical studies indicate that combination therapy results in a reduction in total lesion counts of 50-70%.

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

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