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7-Aminocephalosporanic Acid

  • Chemical Name: 7-Aminocephalosporanic acid
  • CAS No.:957-68-6
  • MF:C10H12N2O5S
  • MW:272.28
  • Specification: USP|EP|BP
  • Purity:>90% or As customer requested
  • Color: Off-white to beige
  • Solubility:409.6mg/L(22.99 ºC)
  • Product Categories: Pharmaceutical intermediate; Antibiotics; Inhibitors; cephalosporins antibiotics; Intermediates & Fine Chemicals
  • Test method: HPLC


7-Aminocephalosporanic Acid, also named as 7beta-aminocephalosporanic acid,  is the alpha,beta-unsaturated monocarboxylic acid that is the active nucleus for the synthesis of cephalosporins and intermediates. It derives from a cephalosporanic acid. It is a tautomer of a 7beta-aminocephalosporanic acid zwitterion. 

Basic information  

Product Name: 7-Aminocephalosporanic acid
Synonyms: Cefazolin Sodium EP Impurity H (7-Aminocephalosporanic Acid); Cephalothin Impurity C(EP)(7-ACA; Aminocephalosporanic; Cefazolin EP Impurity H; 7-ACA Impurity; Ceftriaxone Impurity 18;7-AMinocephalosporanic acid 98%
CAS: 957-68-6
MF: C10H12N2O5S
MW: 272.28
EINECS: 213-485-0
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; Organic acids; API intermediates; API
Chemical Structure

7-Aminocephalosporanic acid            

Chemical Properties  

Melting point  >300 °C (lit.)
alpha  94 º (c=0.5, KH2PO4, PH 7)
Boiling point  560.6±50.0 °C(Predicted)
density  1.4667 (rough estimate)
refractive index  1.5650 (estimate)
storage temp.  2-8°C
pka 2.59±0.50(Predicted)
form  Crystalline Powder
color  Off-white to beige
optical activity [α]19/D +90°, c = 0.5 in KH2PO4/trace NaOH
Water Solubility  409.6mg/L(22.99 ºC)
Merck  14,434
BRN  622638
Stability: Hygroscopic
Usage And Synthesis

Chemical Properties Crystals.
Uses Pharmaceutical intermediates. It is the starting material of many semi-synthetic cephalosporin. A variety of semi-synthetic cephalosporin industrial production is through fermentation to obtain cephalosporin C. Then obtain nucleus 7-ACA through chemical cleavage , and then the preparation is fininshed in chemically modified way .
Chemical Properties Off-white to beige crystalline powder

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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