Wholesale Sialic Acid 99% Powder Price In USA

The biosynthesis production of Sialic Acid 99% (N-acetylneuraminic acid, Neu5Ac) has become the preferred method for large-scale and high-purity manufacturing, especially for pharmaceutical, nutraceutical, and cosmetic industries. Unlike traditional extraction from animal tissues, synthetic biology offers a scalable, animal-free, and sustainable production route that meets modern regulatory and market demands.

Keywords: Food Grade Sialic Acid Powder, Sialic Acid 99% Price, Supplier, Manufacturer, Factory, Wholesale, Biosynthetic.

What Is Sialic Acid?

Sialic acid refers to a family of over 50 derivatives of neuraminic acid, commonly found at the terminal positions of glycoproteins and glycolipids. The final product is tested for:

Purity: ≥99% confirmed by HPLC
Microbial Load: Absence of pathogens and low bioburden
Residual Solvents: Compliant with USP or EP standards
Heavy Metals: Below acceptable limits (Pb, As, Hg, Cd)
Moisture Content: ≤5%

Certificates of Analysis (COA), MSDS, and third-party lab reports are usually provided to wholesale buyers.

Advantages of Synthetic Biological Manufacturing

Animal-free and vegan-compliant
Highly scalable for industrial demand
Consistent purity and reproducibility
Lower environmental impact than animal extraction or chemical synthesis
Ideal for use in regulated markets (EU, USA, Japan)

Manufacturing Process of Sialic Acid Powder

1. Microbial Strain Engineering

Production begins with the genetic modification of safe microbial strains such as Escherichia coli or Corynebacterium glutamicum. Key metabolic pathways are engineered to express genes required for the biosynthesis of Neu5Ac:

neuC: Produces N-acetylmannosamine (ManNAc)
neuB: Converts ManNAc and phosphoenolpyruvate into Neu5Ac
Precursors (glmS, glmM): Convert glucose into ManNAc intermediates

Unnecessary degradation pathways (e.g., nanA) are knocked out to increase yield and stability.

2. Fermentation

The engineered bacteria are cultured in bioreactors under controlled conditions:

Carbon Source: Glucose or glycerol
pH: 6.8–7.2
Temperature: 30–37°C
Aeration: Maintained to ensure optimal oxygen supply

Over a 48–72 hour cycle, Neu5Ac accumulates in the culture broth.

3. Purification

After fermentation, a multi-stage purification process is applied:

Cell Separation: Using centrifugation or membrane filtration
Ultrafiltration: Removes proteins and large molecules
Ion-Exchange Chromatography: Eliminates impurities
Crystallization or Spray Drying: Produces a fine, stable powder with ≥99% purity

Applications

Sialic Acid Powder produced via synthetic biology is widely used in:

Infant formula and cognitive supplements
Pharmaceutical intermediates
Skincare and anti-aging products
Veterinary and functional feed formulations

How Our Clients Use Sialic Acid Powder

1. Brain and Cognitive Health Supplements

Sialic acid is critical for the structure and function of gangliosides in the brain. It supports neurodevelopment, memory retention, and cognitive resilience, especially in early life and aging populations.

Customer Case: U.S. Brain Supplement Brand

A California-based nootropic company incorporated Sialic Acid 99% into a daily memory and brain support capsule aimed at professionals over 40. The product combined sialic acid with phosphatidylserine and Bacopa monnieri. Post-launch feedback and trials showed a 17% increase in customer retention and a marked improvement in attention-span metrics in trial groups.

2. Infant Nutrition and Formula Enhancers

Sialic acid is naturally present in human breast milk and supports brain development and immunity in infants. It is often added to infant formula to mimic the benefits of natural milk oligosaccharides (HMOs).

Customer Case: Southeast Asian Infant Formula OEM

A contract manufacturer in Singapore added Sialic Acid 99% (fermentation-based) to its premium goat milk-based infant formula targeted for export to China and Vietnam. The inclusion helped the product qualify for HMO-equivalent labeling, increasing brand appeal in competitive urban markets.

3. Skin Health and Beauty-from-Within Supplements

Sialic acid contributes to skin hydration, reduces pigmentation, and supports cell regeneration. In nutricosmetics, it is combined with collagen, hyaluronic acid, or elastin-boosting peptides.

Customer Case: Korean Beauty Brand

A Seoul-based cosmeceutical company launched a sialic acid + marine collagen drink stick for daily use, targeting consumers aged 25–45. The product became a regional bestseller on e-commerce platforms, with over 120,000 units sold in the first six months. Consumer surveys cited improved skin smoothness and tone within 4 weeks.

4. Immune and Gut Health Formulations

Sialic acid modulates gut flora, supports mucosal immunity, and can reduce inflammation. It’s increasingly used in immune-boosting supplements for both adults and children.

Customer Case: German Functional Food Company

A wellness food manufacturer added Sialic Acid 99% to a synbiotic chewable tablet alongside probiotics and prebiotics. The product was launched in pharmacies and health stores and promoted as a “gut-brain axis” booster. It achieved a 22% market share within its category in German-speaking countries within one year.

5. Veterinary & Pet Nutrition

Sialic acid improves immune response and gastrointestinal health in young animals.

Customer Case: U.S. Animal Feed Supplier

A livestock nutrition company in the Midwest introduced a sialic acid-enriched milk replacer for calves and piglets. Field trials reported lower mortality rates and faster weight gain in the early weaning phase. The company now includes sialic acid in over 70% of its custom formulations.

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