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Ceftriaxone Sodium

  • Chemical Name: Ceftriaxone sodium
  • CAS No.:104376-79-6
  • MF: C18H19N8NaO7S3
  • MW: 598.54
  • Specification: USP|EP|BP
  • Purity:>98% or As customer requested
  • Chemical Properties: White Crystalline Solid
  • Solubility:Freely soluble in water
  • Product Categories: Pharmaceutical intermediate; Intermediates & Fine Chemicals; Sulfur & Selenium Compounds
  • Test method: HPLC


Ceftriaxone is a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. 

This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS). 

Basic information 

Product Name: Ceftriaxone sodium
Synonyms: Ceftriaxone sodiuM sesquaterhydrate; Ceftriaxone SodiuM Trihydrate; Ceftriaxone disodium salt hemiheptahydrate, >=98%
CAS: 104376-79-6
MF: C18H16N8Na2O7S3.31/2H2O
MW: 598.54
EINECS: 626-956-4
Product Categories: VESPRIN; API ;Intermediates & Fine Chemicals; Pharmaceuticals; Ceftriaxone; Heterocycles; Sulfur & Selenium Compounds
Chemical Structure

Ceftriaxone sodium            

Chemical Properties   

Melting point  236 °C
alpha  D25 -165° (c = 1 in water) (calc for water-free substance)
refractive index  -160 ° (C=1, H2O)
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  H2O: soluble50mg/mL
form  powder or crystals
pka ~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH)
Water Solubility  Freely soluble in water
Usage And Synthesis 

Chemical Properties White Crystalline Solid

An antibacterial, a third-generation cephalosporin.
A potentially useful antibacterial agent for proteomics research.
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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