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Colistin Sulfate (1264-72-8) C52H98N16O13

  • Chemical Name:Colistin sulfate
  • CAS No.:1264-72-8
  • MF: 2(C52H98N16O13).5(H2SO4)
  • MW:2801.27
  • Specification: USP|EP|BP
  • Purity: 98%,99% or As customer requested
  • Chemical Properties: White to off-white powder.
  • Solubility:Soluble in water
  • Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Veterinaries;antibiotic;APIs;Inhibitors
  • Test method: HPLC
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Colistin is a cyclic polypeptide antibiotic of the polymyxin family. It targets the cell membrane of bacteria, which ultimately leads to an altered cell permeability and cell death. It primarily targets gram-negative bacteria. Colistin has been used to study mannose-resistant haemagglutination, antibiotic resistance, and nephrotoxicity.

Polymyxin antibiotic. Binds to lipids on the cell cytoplasmic membrane. Disrupts cell wall integrity. Effective against Gram-negative bacteria. 

Colistin sulfate Basic information 
Product Name: Colistin sulfate
Synonyms: belcomycin; Animal Feed Additives colistin sulfate Colistin Sulfate; Animal Feed Additives colistin sulfate CAS 1264-72-8 Colistin Sulfate; COLISTINE SULFATE; COLISTIN SULPHATE PURE GRADE; Colistin sulphate premix 10% 40%; Polymyxin E . sulfate
CAS: 1264-72-8
MF: 2(C52H98N16O13).5(H2SO4)
MW: 2801.27
EINECS: 215-034-3
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; Active Pharmaceutical Ingredients; Veterinaries; SYNCURINE; antibiotic; API; Inhibitors

Colistin sulfate Chemical Structure

Colistin sulfate            

Colistin sulphate Chemical Properties   
Melting point  200-220°C
storage temp.  2-8°C
solubility  H2O: soluble50mg/mL
form  powder
PH 4.0~6.0(10g/l, 25℃)
Water Solubility  Soluble in water
Merck  14,2479
InChIKey VEXVWZFRWNZWJX-NBKAJXASSA-N
Colistin sulphate Usage And Synthesis    
Chemical Properties White or almost white, hygroscopic powder.
Uses

antibacterial
neuromuscular blocker
Clinical Use Colistimethate sodium
Infections due to Ps. aeruginosa and other Gram-negative rods resistant to less toxic agents
Cystic fibrosis (inhalation therapy for pseudomonas infection)
Polymyxin B and colistin sulfate
Component of preparations for local application
Superficial infections with Ps. aeruginosa and to prevent the colonization of burns
Selective decontamination of the gut and as a paste for control of upper respiratory tract colonization in patients on prolonged mechanical ventilation (in combination with other agents)
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