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Cromoglicic Acid

  • Chemical Name: Cromoglicic acid
  • CAS No.: 16110-51-3
  • MF: C23H16O11
  • MW:468.37
  • Specification: USP|EP|BP
  • Purity: 97% or As customer requested
  • Categories: Pharmaceutical
  • Solubility:Water soluble.
  • Test method: HPLC

Cromoglicic acid (INN)—also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate—is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells.

Cromoglicic acid has been the non-corticosteroid treatment of choice in the treatment of asthma, for which it has largely been replaced by leukotriene receptor antagonists because of their convenience (and perceived safety). Cromoglicic acid requires administration four times daily, and does not provide additive benefit in combination with inhaled corticosteroids.

Cromoglicic Acid Basic information  

Product Name: Cromoglicic acid
Synonyms: 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane;cromoglicic acid;CROMOGLYCATE SODIUM SALT;cromoglycic acid;CROMOGLYCIC ACID SODIUM SALT;CROMOLYN;CROMOLYN SODIUM;CROMOLYN SODIUM SALT
CAS: 16110-51-3
MF: C23H16O11
MW: 468.37
EINECS: 240-279-8
Product Categories: Pharmaceutical
Mol File: 16110-51-3.mol

Cromoglycic Acid Chemical Structure

Cromoglicic acid            

Cromoglicic acid Chemical Properties

Melting point  241-242°C
Boiling point  752.3±60.0 °C(Predicted)
density  1.623
pka pKa 2.0 (Uncertain)
CAS DataBase Reference 16110-51-3(CAS DataBase Reference)
EPA Substance Registry System Cromolyn (16110-51-3)

CROMOLYN SODIUM Usage And Synthesis

Uses It is used for bronchial asthma, as well as prevention of seasonal, constant, and physically caused asthma attacks and allergic rhinitis.
Anti Asthamatic
Definition ChEBI: A dicarboxylic acid that is the bis-chromone derivative of glycerol. It is effective as a mast cell stabilizer.
Manufacturing Process To a solution of 970 parts of 2,6-dihydroxyacetophenone and 325 parts of epichlorohydrin in 1,500 parts of hot isopropanol was added, with stirring under reflux, a solution of 233 parts of 85% KOH in 2,500 parts of isopropanol and sufficient water (ca 100 parts) to dissolve the solid. The mixture was heated, with stirring, under reflux for 48 hours. Half the solvent was then distilled off and 5,000 parts of water were added. The mixture was cooled and the solid filtered off and washed with isopropanol and ether. It was then recrystallized from 12,500 parts of isopropanol to obtain a first crop of 380 parts and a second crop, after concentration, of 300 parts of 1,3-bis(2- acetyl-3-hydroxyphenoxy)-2hydroxypropane.
4.6 parts of 1,3-bis(2-acetyl-3-hydroxyphenoxy)-2-hydroxypropane were reacted with diethyl oxalate and the product cyclized to obtain 4.4 parts of pure diethyl ester of 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane as pale yellow crystals melting between 180° and 182°C from a mixture of benzene and petrol, 4 parts of the diethyl ester of 1,3-bis(2-carboxychromon5-yloxy)-2-hydroxypropane were saponified with sodium hydroxide to obtain 3.2 parts of the disodium salt tetrahydrate as colorless crystals from aqueous alcohol.
Therapeutic Function Bronchodilator
General Description Solid.
Air & Water Reactions Water soluble.

Clinical Use Cromolyn generally is used prophylactically for bronchial asthma (as an inhaled powder), for prevention of exercise-induced bronchospasm, and for seasonal and perennial allergic rhinitis (nasal solution). Topically, it also is used as eye drops for allergic conjunctivitis and keratitis. In the management of asthmatic conditions, it is administered using a power-operated nebulizer. The bioavailability is very low with oral administration because of poor absorption. By inhalation, the powder is irritating to some patients. After inhalation, much less than 10% of the dose reaches the systemic circulation. An oral dosage form is used for mastocytosis.

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