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Ketotifen Fumarate
- Chemical Name: Ketotifen fumarate
- CAS No.: 34580-14-8
- MF: C23H23NO5S
- MW:425.5
- Specification: USP|EP|BP
- Purity:98% or As customer requested
- Water Solubility:Soluble in water (10 mg/ml), DMSO (100 mM), and methanol.
- Chemical Properties:white (or light-yellow) crystalline powder
- Test method: HPLC
Description
What is Ketotifen Fumarate
Ketotifen Fumarate is the fumarate salt of ketotifen, a cycloheptathiophene subordinate with hostile to hypersensitive action.
Ketotifen fumarate powder specifically impedes receptor (H1) receptors and forestalls the average side effects brought about by receptor discharge. This specialist likewise disrupts the arrival of provocative arbiters from pole cells engaged with extreme touchiness responses, subsequently diminishing chemotaxis and actuation of eosinophils.
Zaditor Basic information
Product Name: | Ketotifen fumarate |
Synonyms: | Ketotifene fumarate; 10H-Benzo4,5cyclohepta1,2-bthiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (2E)-2-butenedioate (1:1); zaditor; KETOTIFEN FUMARATE EP; Allerkif; Anatifen; 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate;zaditen |
CAS: | 34580-14-8 |
MF: | C23H23NO5S |
MW: | 425.5 |
EINECS: | 252-100-0 |
Product Categories: | Antagonists; Histaminergics; Neurotransmitters; Histamine receptor; Aromatics; Antiallergic agents; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds; Pharmaceutical raw material; SERC; Other APIs |
Mol File: | 34580-14-8.mol |
Zaditen Chemical Structure
Ketotifen Fumarate Ep Chemical Properties
Melting point | 192 C |
storage temp. | Store at RT |
solubility | Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in acetonitrile. |
form | neat |
PH | pH (10g/l, 25℃) : 3.0~4.0 |
Water Solubility | Soluble in water (10 mg/ml), DMSO (100 mM), and methanol. |
λmax | 297nm(MeOH)(lit.) |
Merck | 14,5307 |
InChIKey | YNQQEYBLVYAWNX-WLHGVMLRSA-N |
CAS DataBase Reference | 34580-14-8(CAS DataBase Reference) |
Ketotifen fumarate Usage And Synthesis
Chemical Properties:
This product is white (or light-yellow) crystalline powder, and is odorless with bitter taste. It is slightly soluble in water and ethanol, and easily soluble in methanol but very slightly soluble in chloroform and acetone.
Indications:
Dermatology applies it to the treatment of allergic diseases such as urticaria, pruritus, eczema, atopic dermatitis, and neurodermatitis; it is recently reported that it is also effective in the treatment of scleroderma. For medicine, it has a good efficacy in treating asthma, especially with a significant effect on treating allergic asthma, followed by mixed asthma, and being effective in half of cases for infecting type. It can also be used for the prevention of asthma.
Ketotifen fumarate is utilized to treat hypersensitive circumstances like conjunctivitis (as eye drops) and asthma (tablets or inhalers) because of its allergy med properties. Ketotifen fumarate likewise goes about as a pole cell stabilizer, diminishing the arrival of normal synthetic substances that trigger hypersensitive reactions, irritation, aviation route fits, and other asthma and sensitivity side effects.
Ketotifen fumarate powder is utilized in the drawn out treatment of asthma, decreasing wheezing and breathing trouble in patients. It is oftentimes utilized close by other asthma meds (corticosteroids like prednisone, breathed in beta-agonists like salbutamol).
MSDS: MSDS available
COA: COA can be available if you send us inquiry.
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