Demeclocycline hydrochloride is the hydrochloride salt of demeclocycline. A tetracycline antibiotic, it is used (mainly as the hydrochloride) for the treatment of Lyme disease, acne and bronchitis, as well as for hyponatraemia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective. It has a role as an antibacterial drug. It contains a demeclocycline. (Source: ChEBI)
Demeclocycline hydrochloride Basic information
|Product Name: ||Demeclocycline hydrochloride |
|Synonyms: ||7-CHLORO-6-DEMETHYLTETRACYCLINE HYDROCHLORIDE; DEMECLOCYCLINE; DEMECLOCYCLINE HYDROCHLORIDE; chlorodemethyltetracyclin hydrochloride; |
|CAS: ||64-73-3 |
|MF: ||C21H21ClN2O8.ClH |
|MW: ||501.32 |
|EINECS: ||200-592-2 |
|Product Categories: ||API; Intermediates & Fine Chemicals; Pharmaceuticals; Amines; |
Demeclocycline hydrochloride Chemical Structure
Demeclocycline hcl Chemical Properties
|Melting point ||>245°C (dec.) |
|storage temp. ||−20°C |
|solubility ||H2O: 20 mg/mL, clear, very deep greenish yellow |
|pka ||pKa 3.3 (Uncertain) |
|form ||powder |
|Water Solubility ||Soluble in water. |
|Merck ||13,2905 |
|BRN ||5705221 |
|InChIKey ||GVSJQNRGSCOSNJ-KBHRXELFSA-N |
Demeclocycline hcl Usage And Synthesis
|Chemical Properties ||Yellow Solid |
|Uses ||An antibiotic related to tetracycline and produced by streptomyces aureofaciens. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time |
|Antibacterial; Ribosomal protein synthesis inhibitor |
|Demeclocycline hydrochloride is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. |
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