Levocetirizine Dihydrochloride

Description

What is Levocetirizine Dihydrochloride?

Levocetirizine Dihydrochloride is the dihydrochloride salt form of the active levorotatory enantiomer of cetirizine, levocetirizine; a third generation, non-sedating, selective histamine H1 receptor antagonist, with antihistamine, anti-inflammatory and potential anti-angiogenic activities. Levocetirizine competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface.

This prevents the negative symptoms associated with histamine release and an allergic reaction. In addition, as histamine plays an important role in angiogenesis during an allergic inflammatory reaction, blocking the action of histamine may modulate the expression of proangiogenic factors and thus may prevent angiogenesis. As a third-generation histamine H1 receptor antagonist, levocetirizine has fewer side effects than most second-generation antihistamines.

Xusal Basic information

Product Name:	Levocetirizine dihydrochloride
Synonyms:	LEVOCETIRIZINE 2HCL;LEVOCETIRIZINE DIHCL;LEVOCETIRIZINE DIHYDROCHLORIDE;LEVOCETIRIZINE HCL;LEVOCETRIZINE DIHYDROCHLORIDE;[2-[4-[(r)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride;[2-[4-[(R)-(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINYL]ETHOXY]-ACETIC ACID 2HCL;(R)-Cetirizine (hydrochloride)
CAS:	130018-87-0
MF:	C21H27Cl3N2O3
MW:	461.81
EINECS:	641-093-3
Product Categories:	Antibiotics; Levocitirizine 2HCl; API’s; Levocetirizine; Histamine receptor; API
Mol File:	130018-87-0.mol

Xyzal Chemical Structure

Levocetirizine dihydrochloride

Levocetirizine Dihydrochloride Chemical Properties

Melting point	215-220°C
alpha	D25 -12.79° (c = 1 in water)
storage temp.	room temp
solubility	H2O: ≥23mg/mL
form	powder
Merck	14,2022
CAS DataBase Reference	130018-87-0(CAS DataBase Reference)