Cetirizine Hydrochloride

Description

Cetirizine Hydrochloride Description

Cetirizine hydrochloride is known as a non-drowsy antihistamine. It’s much less likely to make you feel sleepy than some other antihistamines.

Hydrochloride cetirizine is available on prescription, but you can also buy it from pharmacies and supermarkets.

It comes as tablets, capsules and as a liquid that you swallow.

It’s usual to take cetirizine once a day. Children aged under 12 take it twice a day.

Cetirizine hydrochloride is classed as a non-drowsy antihistamine, but some people still find it makes them feel quite sleepy.

Common side effects include headaches, dry mouth, feeling sick, dizziness and diarrhoea.

Some brands of hydrochloride cetirizine come as capsules. These may contain soya oil. Do not take cetirizine capsules if you are allergic to peanuts or soya.

Zyrtec Basic information

Product Name:	Cetirizine hydrochloride
Synonyms:	(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)aceticaciddihydro; 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride; Cetirizine Hydrochloride (250 mg); Alercet; Alerid; Cesta; Cetiriz; Cetrak
CAS:	83881-52-1
MF:	C21H26Cl2N2O3
MW:	425.35
EINECS:	620-533-8
Product Categories:	API; Intermediates & Fine Chemicals; Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals;Pharmaceuticals; DOPRAM; Histamine receptor; Aromatics; Heterocycles; Metabolites & Impurities
Mol File:	83881-52-1.mol

Reactine Chemical Structure

Cetirizine hydrochloride

Cetirizine Dihcl Chemical Properties

Melting point	110-115°C
storage temp.	Desiccate at RT
solubility	H2O: soluble5mg/mL, clear
form	powder
color	white to beige
Water Solubility	Soluble in water, DMSO, ethanol, and methanol.
Merck	14,2022
InChIKey	PGLIUCLTXOYQMV-UHFFFAOYSA-N
CAS DataBase Reference	83881-52-1(CAS DataBase Reference)
EPA Substance Registry System	Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2) (83881-52-1)

Cetirizine Hydrochloride Usage And Synthesis

Description	Cetirizine hydrochloride is a once-daily, non-sedating antihistamine useful in the treatment of allergic rhinitis, urticaria and conjunctivitis. It is reported to be more effective than most other agents in this category such as terfenadine and astemizole.
Chemical Properties	Crystalline Solid
Uses	respiratory stimulant
	A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.
	long acting calcium channel blocker
	Antihistaminic
Indications	Cetirizine HCl (Zyrtec) is the carboxylic acid metabolite of hydroxyzine. It is a selective, peripheral H1 receptor antagonist. It is a long-lasting antihistamine. It does not appear to have the same adverse cardiac effects as the other nonsedating H1 antihistamines; however, additional data are required. Indicated for allergic rhinitis and chronic urticaria.
Therapeutic Function	Antihistaminic; Antiallergic
Biological Activity	Histamine H 1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μ M. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo .