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Cetirizine Hydrochloride (83881-52-1) C21H26Cl2N2O3

  • Chemical Name: Cetirizine hydrochloride
  • CAS No.: 83881-52-1
  • MF:C21H26Cl2N2O3
  • MW: 425.35
  • Specification: USP|EP|BP
  • Purity:98%+ or As customer requested
  • Color: white to beige
  • Solubility:Soluble in water, DMSO, ethanol, and methanol.
  • Test method: HPLC

Cetirizine Hydrochloride Description       

Cetirizine hydrochloride is an orally-active and selective histamine (H1)-receptor antagonist. It is a second-generation antihistamine and a human metabolite of hydroxyzine. Three important features of cetirizine are: a high specificity fort he H1-receptor; a low need for metabolism, and the existence of non-H1-dependent activities on cells involved in the pathogenesis of allergy.

Cetirizine is used to treat seasonal allergic rhinitis (SAR), perennial allergic rhinitis, useful in treating urticaria and atopic dermatitis. Cetirizine possesses also mild anti-inflammatory effects.

Zyrtec Basic information 

Product Name: Cetirizine hydrochloride
Synonyms: (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)aceticaciddihydro; 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride; Cetirizine Hydrochloride (250 mg); Alercet; Alerid; Cesta; Cetiriz; Cetrak
CAS: 83881-52-1
MF: C21H26Cl2N2O3
MW: 425.35
EINECS: 620-533-8
Product Categories: API; Intermediates & Fine Chemicals; Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals;Pharmaceuticals; DOPRAM; Histamine receptor; Aromatics; Heterocycles; Metabolites & Impurities
Mol File: 83881-52-1.mol

Reactine Chemical Structure

Cetirizine hydrochloride            

Cetirizine Dihcl Chemical Properties    

Melting point  110-115°C
storage temp.  Desiccate at RT
solubility  H2O: soluble5mg/mL, clear
form  powder
color  white to beige
Water Solubility  Soluble in water, DMSO, ethanol, and methanol.
Merck  14,2022
CAS DataBase Reference 83881-52-1(CAS DataBase Reference)
EPA Substance Registry System Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2) (83881-52-1)

Cetirizine Hydrochloride Usage And Synthesis

Description Cetirizine hydrochloride is a once-daily, non-sedating antihistamine useful in the treatment of allergic rhinitis, urticaria and conjunctivitis. It is reported to be more effective than most other agents in this category such as terfenadine and astemizole.
Chemical Properties Crystalline Solid


respiratory stimulant
A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.
long acting calcium channel blocker
Indications Cetirizine HCl (Zyrtec) is the carboxylic acid metabolite of hydroxyzine. It is a selective, peripheral H1 receptor antagonist. It is a long-lasting antihistamine. It does not appear to have the same adverse cardiac effects as the other nonsedating H1 antihistamines; however, additional data are required. Indicated for allergic rhinitis and chronic urticaria.
Therapeutic Function Antihistaminic; Antiallergic
Biological Activity Histamine H 1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μ M. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo .

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

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