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Faropenem Sodium Hemipentahydrate (106560-14-9) C12H15NO5S

  • Chemical Name: Faropenem sodium hemipentahydrate
  • CAS No.: 106560-14-9
  • MF: C12H15NO5S
  • MW:285.32
  • Specification: USP|EP|BP
  • Purity:90%,95%,99% or As customer requested
  • Product Categories: API
  • Test method: HPLC

Maxmedchem, a global supplier of Faropenem sodium hemipentahydrate, 106560-14-9 offers for your requirements of RND / Development quantities or commercials, based on status of the product. We can also offer its intermediates with supportive technical package required for evaluation.

Faropenem sodium hemipentahydrate was launched in Japan for use as an antibiotic against common respiratory tract pathogens. It can be prepared by several related routes of about seven steps starting with tetrahydrofuran-2-thiocarboxylic acid and a silylated azetidinone. It is a broad spectrum oral penem antibiotic that is β-lactamase stable. Farom is the most active β-lactam against anaerobes (more than cefaclor, cefixime and amoxicillin) but also has activity against Gram-positive, Gram-negative and enterobacteriaceae. It is equally active against strains carrying plasmid and chromosome mediated β-lactamases. The short plasma elimination half-life is the result of hydrolysis by renal dehydropeptidase. It is more stable to hydrolysis by extended spectrum β-lactamases than some second and third generation cephalosporins.

Faropenem Sodium Hemipentahydrate Basic information

Product Name: Faropenem sodium hemipentahydrate
Synonyms: (+)-(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-(1-hydroxyethyl)-2-penem-3-carboxylic acid; 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-, [5R-[3(R*),5α,6α(R*)]]-; 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-, (5R,6S)-; 6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt hemipentahydrate; Faropenem sodium hemipentahydrate; FAROPENEM; FROPENEM
CAS: 106560-14-9
MF: C12H15NO5S
MW: 285.32
EINECS: 1312995-182-4
Product Categories: API
Mol File: 106560-14-9.mol

Faropenem Sodium Chemical Structure

Faropenem sodium hemipentahydrate            

Faropenem Sodium Hydrate Chemical Properties      
Boiling point  570.2±50.0 °C(Predicted)
density  1.56±0.1 g/cm3(Predicted)
pka 4.00±0.40(Predicted)
CAS DataBase Reference 106560-14-9

Farom Usage And Synthesis

Originator Suntory (Japan)
Uses Treatmentof bacterial infections.
Antimicrobial activity An orally active penem with a broad spectrum of antibacterial activity, including activity against selected anaerobic pathogens. Although it is active against most enterobacteria, it has reduced activity against Ser. marcescens, Enterobacter spp. and some Providencia spp. It generally retains activity against many Gram-positive organisms, but has no useful activity against Ps. aeruginosa. It has reduced activity against E. faecium, methicillin-resistant Staph. aureus (MRSA) and some strains of coagulase-negative staphylococci. It is stable to hydrolysis by extended spectrum β-lactamases, but is hydrolyzed by carbapenemases. Esterified prodrugs with increased bioavailability have been studied in clinical trials but have not received regulatory approval.

MSDS: MSDS available

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