Fosfomycin Tromethamine

Description

What is Fosfomycin Tromethamine?

Fosfomycin Tromethamine is the tromethamine salt form of fosfomycin, a synthetic broad-spectrum antibiotic. Fosfomycin tromethamine binds to and inactivates the enzyme enolpyruvyl transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis. In addition, fosfomycin tromethamine reduces the adherence of bacteria to uroepithelial cells. (NCI05)

Basic information

Product Name:	Fosfomycin tromethamine
Synonyms:	Fosfomycin trometamol USP; FOSFOMYCIN TROMETAMOL;
CAS:	78964-85-9
MF:	C7H18NO7P
MW:	259.19
EINECS:	279-018-8
Product Categories:	API; Antibiotics

Chemical Structure

Fosfomycin tromethamine

Chemical Properties

solubility	Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.
InChIKey	QZJIMDIBFFHQDW-LMLSDSMGSA-N

Fosfomycin tromethamine Uses And Synthesis

Fosfomycin tromethamine is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

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