Azelastine Hydrochloride

Description

Azelastine hydrochloride Description

Azelastine Hydrochloride is the hydrochloride salt form of azelastine, a phthalazinone derivative with antihistaminergic activity.

Azelastine hydrochloride competes with histamine for the H1 receptor, thereby diminishing the actions of histamine on effector cells and decreasing the histamine-mediated symptoms of allergic reaction, such as bronchoconstriction, vasodilation, increased capillary permeability and spasmodic contractions of gastrointestinal smooth muscle. (Source: NCI Thesaurus (NCIt))

Azelastine Hcl Basic information

Product Name:	Azelastine hydrochloride
Synonyms:	a5610;azeptin;e-0659;w-2979m;AZELASTINE HCL;AZELASTINE HYDROCHLORIDE;4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one hydrochloride;4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride
CAS:	79307-93-0
MF:	C22H25Cl2N3O
MW:	418.36
EINECS:	620-469-0
Product Categories:	Antihistaminic; Astelin; Intermediates & Fine Chemicals; Pharmaceuticals; Histamine receptor
Mol File:	79307-93-0.mol

Astelin Chemical Structure

Azelastine hydrochloride

Allergodil Chemical Properties

Melting point	225–2290C
storage temp.	-20°C Freezer
solubility	DMSO: >10mg/mL
form	powder
color	white to off-white
Merck	14,906
Stability:	Incompatible with strong oxidizing agents.
CAS DataBase Reference	79307-93-0(CAS DataBase Reference)

Azelastine Hydrochloride Usage And Synthesis

Description	Azelastine hydrochloride is an orally effective antihistamine useful in the treatment of asthma and nasal allergy. It appears to inhibit release of histamine, in addition to antagonizing its action.
Chemical Properties	White or almost white, crystalline powder.
Uses	Orally active H1-hystamine receptor antagonist. Antihistaminic
Definition	ChEBI: The hydrochloride salt of azelastine.