Promethazine Hydrochloride

Description

What is Promethazine Hydrochloride?

Promethazine Hydrochloride is the hydrochloride salt form of promethazine, a phenothiazine derivative with antihistaminic, sedative and antiemetic properties. Hydrochloride promethazine selectively blocks peripheral H1 receptors thereby diminishing the effects of histamine on effector cells.

Promethazine hydrochloride also blocks the central histaminergic receptors, thereby depressing the reticular system causing sedative and hypnotic effects. In addition, hydrochloride promethazine also has centrally acting anticholinergic properties and probably mediates nausea and vomiting by acting on the medullary chemoreceptive trigger zone. (Source: NCI Thesaurus (NCIt))

Promethazine Hcl Basic information

Product Name:	Promethazine hydrochloride
Synonyms:	10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride; PROMETHAZINE HCL; PROMETHAZINE HYDROCHLORIDE; PHENERGAN; 10-(2-(dimethylamino)propyl)phenothiazinemono hydrochloride; 10-(2-(dimethylamino)propyl)-phenothiazinmono hydrochloride; promethazinen-(2’-dimethylamino-2’-methylethyl)phenothiazine hydrochloride; promethiazin
CAS:	58-33-3
MF:	C17H21ClN2S
MW:	320.88
EINECS:	200-375-2
Product Categories:	Inhibitors; API; Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals; COLACE; Sulfur & Selenium Compounds; Histamine receptor
Mol File:	58-33-3.mol

Phenergan Chemical Structure

Promethazine hydrochloride

Fenergan Chemical Properties

Melting point	230-232°C
Fp	9℃
storage temp.	Refrigerator
solubility	Very soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
form	neat
PH	pH (50g/L, 25℃) : 4.0～6.0
λmax	297nm(H2O)(lit.)
Merck	14,7786
BRN	4166397
InChIKey	XXPDBLUZJRXNNZ-UHFFFAOYSA-N
CAS DataBase Reference	58-33-3(CAS DataBase Reference)
EPA Substance Registry System	Promethazine hydrochloride (58-33-3)

Atosil Usage And Synthesis

Chemical Properties	White Solid
Uses	Antihistaminic, antiemetic, CNS depressant
	stool softener
	For the treatment of allergic disorders, and nausea/vomiting.
	Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively. Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM). Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.
	Promethazine hydrochloride is used as antihistamine; antiemetic; central nervous system depressant; sedative; anticholinergic; antiserotoninergic; local anesthetic; in the treatment of motion sickness, cough linctuses, nausea, and allergic conditions; used to control Parkinsonian symptoms and as central nervous system depressant; in pills, syrup, injections and suppositories.
Definition	ChEBI: The hydrochloride salt of promethazine.
General Description	Odorless white to faint yellow crystalline powder. Bitter taste. A 10% solution in water has a pH of 3.5-5.0.
General Description	Promethazine hydrochloride,(±)10-[2-(dimethylamino)-propyl]phenothiazinemonohydrochloride (Phenergan), occurs as a white tofaint yellow crystalline powder that is very soluble in water,in hot absolute alcohol, and in chloroform. Its aqueous solutionsare slightly acid to litmus.
Air & Water Reactions	Slowly oxidizes in air, acquiring a blue color. Also turns blue on exposure to moisture. Water soluble.