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Promethazine Hydrochloride

  • Chemical Name: Promethazine hydrochloride
  • CAS No.: 58-33-3
  • MF: C17H21ClN2S
  • MW:320.88
  • Specification: USP|EP|BP
  • Purity:99% or As customer requested
  • Chemical Properties:White Solid
  • Solubility:Good soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
  • Test method: HPLC


What is Promethazine Hydrochloride?      

Promethazine Hydrochloride is the hydrochloride salt form of promethazine, a phenothiazine derivative with antihistaminic, sedative and antiemetic properties. Hydrochloride promethazine selectively blocks peripheral H1 receptors thereby diminishing the effects of histamine on effector cells. 

Promethazine hydrochloride also blocks the central histaminergic receptors, thereby depressing the reticular system causing sedative and hypnotic effects. In addition, hydrochloride promethazine also has centrally acting anticholinergic properties and probably mediates nausea and vomiting by acting on the medullary chemoreceptive trigger zone. (Source: NCI Thesaurus (NCIt))

Promethazine Hcl Basic information    

Product Name: Promethazine hydrochloride
Synonyms: 10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride; PROMETHAZINE HCL; PROMETHAZINE HYDROCHLORIDE; PHENERGAN; 10-(2-(dimethylamino)propyl)phenothiazinemono hydrochloride; 10-(2-(dimethylamino)propyl)-phenothiazinmono hydrochloride; promethazinen-(2’-dimethylamino-2’-methylethyl)phenothiazine hydrochloride; promethiazin
CAS: 58-33-3
MF: C17H21ClN2S
MW: 320.88
EINECS: 200-375-2
Product Categories: Inhibitors; API; Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals; COLACE; Sulfur & Selenium Compounds; Histamine receptor
Mol File: 58-33-3.mol

Phenergan Chemical Structure

Promethazine hydrochloride            

Fenergan Chemical Properties


Melting point  230-232°C
Fp  9℃
storage temp.  Refrigerator
solubility  Very soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
form  neat
PH pH (50g/L, 25℃) : 4.0~6.0
λmax 297nm(H2O)(lit.)
Merck  14,7786
BRN  4166397
CAS DataBase Reference 58-33-3(CAS DataBase Reference)
EPA Substance Registry System Promethazine hydrochloride (58-33-3)

Atosil Usage And Synthesis

Chemical Properties White Solid

Antihistaminic, antiemetic, CNS depressant
stool softener
For the treatment of allergic disorders, and nausea/vomiting.
Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively. Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM). Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.
Promethazine hydrochloride is used as antihistamine; antiemetic; central nervous system depressant; sedative; anticholinergic; antiserotoninergic; local anesthetic; in the treatment of motion sickness, cough linctuses, nausea, and allergic conditions; used to control Parkinsonian symptoms and as central nervous system depressant; in pills, syrup, injections and suppositories.
Definition ChEBI: The hydrochloride salt of promethazine.
General Description Odorless white to faint yellow crystalline powder. Bitter taste. A 10% solution in water has a pH of 3.5-5.0.
Promethazine hydrochloride,(±)10-[2-(dimethylamino)-propyl]phenothiazinemonohydrochloride (Phenergan), occurs as a white tofaint yellow crystalline powder that is very soluble in water,in hot absolute alcohol, and in chloroform. Its aqueous solutionsare slightly acid to litmus.
Air & Water Reactions Slowly oxidizes in air, acquiring a blue color. Also turns blue on exposure to moisture. Water soluble.

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

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