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  • Chemical Name: Menadione
  • CAS No.:58-27-5
  • MF:C11H8O2
  • MW:172.18
  • Purity:≥99% or according to customer requested
  • Color: Yellow powder
  • Product Categories: Biochemistry;Vitamins;Vitamin Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals
  • Test method: HPLC


What is Menadione?

Menadione is an essential fat soluble vitamin that is important in maintaining normal coagulation, serving as a cofactor in the activation of several clotting factors and anticoagulant proteins. There is no evidence that vitamin K supplementation, in physiologic or even higher doses, causes serum enzyme elevations, liver injury or jaundice.

Menadione is a member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia. It has a role as a nutraceutical, a human urinary metabolite, an angiogenesis inhibitor, an EC (SARS coronavirus main proteinase) inhibitor and an antineoplastic agent. It is a member of 1,4-naphthoquinones and a vitamin K. 

Basic information   

Product Name: Menadione
Synonyms: VITAMIN K3; Vitamin K3;menadione k3; MENADIONE POWDER USP;

menadione vitamin k; menadione sodium bisulphate;  menadione sodium bisulfite

CAS: 58-27-5
MF: C11H8O2
MW: 172.18
EINECS: 200-372-6
Product Categories: Biochemistry;Vitamins;Vitamin Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals
Chemical Structure


Chemical Properties   

Melting point  105-107 °C(lit.)
Boiling point  262.49°C (rough estimate)
density  1.1153 (rough estimate)
refractive index  1.5500 (estimate)
storage temp.  room temp
solubility  oil: soluble
form  crystalline
color  yellow
Odor Slight odor
Water Solubility  INSOLUBLE
Sensitive  Light Sensitive
Merck  14,5831
BRN  1908453
Stability: Stable. May be light sensitive. Incompatible with strong oxidizing agents.
Menadione Uses And Synthesis           

What is menadione used for?

The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. Menadione (Vitamin K3) is a fat-soluble vitamin precursor that is converted into menaquinone in the liver. Vitamin K1 and K2 are the naturally occurring types of vitamin K.

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