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Menadione
- Chemical Name: Menadione
- CAS No.:58-27-5
- MF:C11H8O2
- MW:172.18
- Purity:≥99% or according to customer requested
- Color: Yellow powder
- Product Categories: Biochemistry;Vitamins;Vitamin Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals
- Test method: HPLC
Description
What is Menadione?
Menadione is an essential fat soluble vitamin that is important in maintaining normal coagulation, serving as a cofactor in the activation of several clotting factors and anticoagulant proteins. There is no evidence that vitamin K supplementation, in physiologic or even higher doses, causes serum enzyme elevations, liver injury or jaundice.
Menadione is a member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia. It has a role as a nutraceutical, a human urinary metabolite, an angiogenesis inhibitor, an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor and an antineoplastic agent. It is a member of 1,4-naphthoquinones and a vitamin K.
Basic information
Chemical Structure
Chemical Properties
| Melting point | 105-107 °C(lit.) |
| Boiling point | 262.49°C (rough estimate) |
| density | 1.1153 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | room temp |
| solubility | oil: soluble |
| form | crystalline |
| color | yellow |
| Odor | Slight odor |
| Water Solubility | INSOLUBLE |
| Sensitive | Light Sensitive |
| Merck | 14,5831 |
| BRN | 1908453 |
| Stability: | Stable. May be light sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | MJVAVZPDRWSRRC-UHFFFAOYSA-N |
Menadione Uses And Synthesis
What is menadione used for?
The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. Menadione (Vitamin K3) is a fat-soluble vitamin precursor that is converted into menaquinone in the liver. Vitamin K1 and K2 are the naturally occurring types of vitamin K.
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