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Minocycline Hydrochloride (13614-98-7) C23H28ClN3O7

  • Chemical Name:Minocycline hydrochloride
  • CAS No.:13614-98-7
  • MF: C23H28ClN3O7
  • MW:493.94
  • Specification: USP|EP|BP
  • Purity: >98% or As customer requested
  • Appearance: yellow powder
  • Solubility:Freely soluble in water
  • Product Categories: antibiotic;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;API;
  • Test method: HPLC
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Minocycline Hydrochloride is the hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline's neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes. (Source: NCI Thesaurus (NCIt))

Minocycline hydrochloride Basic information    
Product Name: Minocycline hydrochloride
Synonyms: KlinoMycin, Minocycline chloride, MinoMycin, NSC 141993; Minocycline hydrochloride Solution, 100ppm; Minocycline hydrochloride, >=98%; 
CAS: 13614-98-7
MF: C23H28ClN3O7
MW: 493.94
EINECS: 237-099-7
Product Categories: DAYPRO; antibiotic; Antibiotic Explorer; Intermediates & Fine Chemicals; Pharmaceuticals; API; Antibacterial; Peptide Synthesis/Antibiotics
Mol File: 13614-98-7.mol

Minocycline hydrochloride Chemical Structure

Minocycline hydrochloride            
Minocycline hcl Chemical Properties    
Melting point  205-210° (dec)
Boiling point  813℃
Fp  >110°(230°F)
storage temp.  2-8°C
solubility  Sparingly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and carbonates.
form  crystalline
color  yellow
Water Solubility  Freely soluble in water
Merck  14,6202
Stability: Light Sensitive
InChIKey GLMUAFMGXXHGLU-VQAITOIOSA-N
CAS DataBase Reference 13614-98-7(CAS DataBase Reference)

Minomycin Usage And Synthesis


Chemical Properties Yellow Crystalline Powder

Uses

Second generation tetracycline antibiotic. Antibacterial.
antiinflammatory
Minocycline hydrochloride is a salt prepared from minocycline, taking advantage of the two basic dimethylamino groups which protonate and readily form a salt from hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, minocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
Therapeutic Function Antibiotic
Veterinary Drugs and Treatments Minocycline may be useful for treating Brucellosis (in combination with aminoglycosides), Lyme disease, and certain nosocomial infections where other more commonly used drugs are ineffective. It has been investigated as adjunctive therapy for treating hemangiosarcomas, but early results have been disappointing.

MSDS: MSDS available

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