Email Phone Custom Custom


Please enable JavaScript in your browser to complete this form.


  • Chemical Name: Nabumetone
  • CAS No.: 42924-53-8
  • MF:C15H16O2
  • MW:228.29
  • Purity:≥98% or according to customer requested
  • Color: white powder
  • Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;API;Anti-Inflammatory
  • Test method: HPLC


What is Nabumetone?

Nabumetone is a naphthylalkanone and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Nabumetone is a prodrug that upon hepatic catalysis converts into the active moiety 6-methoxy-2-naphthylacetic acid (6MNA). 6MNA inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of nabumetone. The formation of thromboxane A2, by thromboxane synthase, is also decreased and results in an inhibition of platelet aggregation.


Product Name: Nabumetone
Synonyms: NABUMETONE; Nabumeton; Nabumetone EP; Nabumetona; Nabumetonum
CAS: 42924-53-8
MF: C15H16O2
MW: 228.29
EINECS: 611-790-7
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; Aromatics; API; Active Pharmaceutical Ingredients
Chemical Structure


Chemical Properties    

Melting point  80-810C
Boiling point  330.1°C (rough estimate)
density  1.0657 (rough estimate)
refractive index  1.5542 (estimate)
storage temp.  Sealed in dry,2-8°C
solubility  Soluble in alcohol or chloroform
form  neat
Water Solubility  6mg/L(22.5 ºC)
Nabumetone Uses

Nabumetone is a methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a cyclooxygenase 2 inhibitor and a prodrug. It is a methoxynaphthalene and a methyl ketone.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

Email us at: for more details.

Packaging and Shipping




Please enable JavaScript in your browser to complete this form.