Netilmicin Sulfate

Description

Netilmicin Sulfate is the sulfate salt form of netilimicin, a semisynthetic, water soluble aminoglycoside antibiotic. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death. (Source: NCI Thesaurus (NCIt))

Netilmicin sulfate Basic information

Product Name:	Netilmicin sulfate
Synonyms:	D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-N1-ethyl-, sulfate (2:5);Netilmicin sulfhate;Netilmicin sulfate(2:5);Netilmicin sulphate, 1-N-Ethylsisomicin;6-diamino-2,3,4,6-tetradeoxy-alpha-d-glycero-hex-4-enopyranosyl-(1-4)-6)-o-(;netromycin;sulfate(2:5)(salt);Sulfate NetilMicin
CAS:	56391-57-2
MF:	C42H92N10O34S5
MW:	1441.55
EINECS:	260-147-3
Product Categories:	Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals
Mol File:	56391-57-2.mol

Netilmicin sulfate Chemical Structure

Netilmicin sulfate

Nettacin Chemical Properties

Melting point	>194°C (dec.)
Boiling point	868℃
storage temp.	2-8°C
solubility	H2O: soluble10mg/mL
color	white to faint yellow
Water Solubility	Soluble in water
Sensitive	Light Sensitive & Hygroscopic
EPA Substance Registry System	Netilmicin sulfate (56391-57-2)