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Piroxicam (36322-90-4 ) C15H13N3O4S

  • Chemical Name: Piroxicam
  • CAS No.:36322-90-4
  • MF:C15H13N3O4S
  • MW: 331.35
  • Purity: >98% or As customer requested
  • Chemical Properties: Off-White to Pale Yellow Solid
  • Water Solubility:Soluble in water, ethanol, chloroform, ethyl acetate.
  • Product Categories: Active Pharmaceutical Ingredients; APIs; Piroxicam; Intermediates & Fine Chemicals; Pharmaceuticals;
  • Test method: HPLC
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What is Piroxicam?

Piroxicam is a nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects. (Source: NCI Thesaurus (NCIt))

Piroxicam is indicated for the treatment of rheumatoid arthritis and osteoarthritis. Piroxicam is a nonspecific COX inhibitor that has a much higher affinity for COX-1 than COX-2. This may account for the large proportion (over 30%) of patients receiving long-term therapy who have reported side effects.Adverse GI reactions have been the most frequently reported side effect, but edema, dizziness, headache, rash, and changes in hematological parameters have also occurred in 1 to 6% of patients. Piroxicam can cause serious GI bleeding, ulceration, and perforation, particularly in the elderly, if the recommended dosage is exceeded or if aspirin is being taken concurrently.

Basic information   
Product Name: Piroxicam
Synonyms: Pipoxicam; Piroxicamum; Pyroxycam; Roxicam; piroflex; larapam
CAS: 36322-90-4
MF: C15H13N3O4S
MW: 331.35
EINECS: 252-974-3
Product Categories: Sulfur & Selenium Compounds; Active Pharmaceutical Ingredients; APIs; Piroxicam; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals
Chemical Structure

Piroxicam            

Chemical Properties   
Melting point  198-200°C
density  1.3664 (rough estimate)
refractive index  1.6320 (estimate)
storage temp.  2-8°C
solubility  Practically insoluble in water, soluble in methylene chloride, slightly soluble in anhydrous ethanol. It shows polymorphism (5.9).
form  neat
pka 6.3 (2:1 dioxane-water)
Water Solubility  Soluble in water, ethanol, chloroform, ethyl acetate.
λmax 358nm(H2O)(lit.)
Merck  14,7506
InChIKey QYSPLQLAKJAUJT-UHFFFAOYSA-N
Usage And Synthesis

           

Description Piroxieam is a non-steroidal anti-inflammatory drug, of the oxieam class. A contact and photocontact sensitizer, which induced contact dermatitis in a physieal therapist. Piroxieam generally cross reacts with thiosalicylic acid and also with thiomersal. Cross sensitivity is not observed to tenoxicam.
Chemical Properties Off-White to Pale Yellow Solid
Uses

Piroxicam is used in inflammatory and degenerative diseases of the musculoskeletal system that are accompanied by painful symptoms. It is used for rheumatic heart disease, nonspecific infectious polyarthritis, gouty arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, myalgia, and other diseases associated with inflammation.
Non-steroidal anti-inflammatory with long half-life. Cyclooxygenase inhibitor. Clinically useful NSAID


Drug-related effects of piroxicam

1 When drinking alcohol or taking with other anti-inflammatory drugs, gastrointestinal adverse reactions increase;

2 When used together with anticoagulants such as dicoumarin, the latter has an enhanced effect and a significant bleeding tendency, so the dosage should be adjusted;

3 When used with aspirin, the blood concentration of this product can be reduced to 80% of the general concentration, and the risk of gastrointestinal ulcer formation and bleeding tendency increases.

Side effects of piroxicam

1.The most common gastrointestinal adverse reactions such as nausea, stomach pain, reduced appetite and indigestion, 3.5% of which require withdrawal for this purpose. The incidence of gastric ulcer is significantly increased when the dosage of the drug is greater than 20 mg per day, and some are combined with bleeding or even perforation;

2.Neutropenia, eosinophilia, increased blood urea nitrogen, dizziness, dizziness, tinnitus, headache, general weakness, edema, rash or itching, etc.;

3.Abnormal liver function, thrombocytopenia, hyperhidrosis, skin ecchymosis, peeling, erythema multiforme, toxic epithelial necrosis, bullous erythema multiforme (Stevens-Johnson syndrome), skin allergic reaction to light, blurred vision, Red and swollen eyes, high blood pressure, hematuria, hypoglycemia, depression, insomnia and mental stress.

Technical Support & Resources     

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

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Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

Email us at: info@maxmedchem.com for more details.

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