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Polymyxin B Sulfate(1405-20-5)C56H100N16O17S

  • Chemical Name: Polymyxin B Sulfate
  • CAS No.:1405-20-5
  • MF: C56H100N16O17S
  • MW: 1301.56
  • Purity:≥98% or according to customer requested
  • Color: colorless or slightly yellow
  • Product Categories: Pharmaceuticals; Active Pharmaceutical Ingredients; Inhibitors; API; Antibiotics
  • Test method: HPLC

What is Polymyxin B Sulfate?

A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic. (Source: Medical Subject Headings (MeSH))

Polymyxin B sulfate introduction
Product Name: Polymyxin B sulfate
Synonyms: POLYMYXIN B; POLYMYXIN B SULFATE; POLYMYXIN B SULFATE SALT; POLYMYXIN B SULPHATE; POLYMYXIN B (PMB); POLYMIXIN B SULFATE; Aerosporin; Polymyxin B sulfate salt; Polymixin B sulfate salt; sufuric acid
CAS: 1405-20-5
MF: C56H100N16O17S
MW: 1301.56
EINECS: 215-774-7
Product Categories: Pharmaceuticals; Active Pharmaceutical Ingredients; Inhibitors; API; Antibiotics
Chemical Structure

Polymyxin B sulfate            

Chemical Properties
Melting point 217-220°C (dec.)
storage temp. 2-8°C
solubility H2O: 50 mg/mL
pka pKa 8.9 (Uncertain)
form powder
color colorless or slightly yellow
PH pH (10g/L, 25℃) : 4.5~7.0
optical activity [α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees)
Water Solubility Soluble in water at 50mg/ml/n
Polymyxin B sulfate Uses And Synthesis

Polymyxin B is a kind of anti-Gram-negative poly-peptide antibiotics which can alter membrane structure allowing small molecules leakage and inhibit the growth of Gram-negative bacteria. It has bactericidal effect on Escherichia coli through binding to the lipid A portion of bacterial lipopolysaccharide. Mechanism of action: bind and interfere with the permeability o the cellular membrane. Anti-bacteria spectrum: gram negative bacteria.

The side effects of Polymyxin B sulfate

1. Renal toxicity: increased blood urea nitrogen and serum creatinine, occasionally renal failure and acute tubular necrosis. 

2. Neurotoxicity is also common. Temporary nervous system changes such as dizziness, vertigo, ataxia, dull speech, blurred vision, drowsiness, confusion, limb numbness, abnormal taste, etc. 

3. Large doses can cause neuromuscular blockade and cause respiratory arrest. 

4. Allergic reactions: allergic reactions can also occur, such as itching, rash, drug fever, etc., and shock in severe cases. 

5. Occasionally, it can cause leukopenia and liver toxicity. 

6. Obvious pain after intramuscular injection.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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