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Retapamulin

  • Chemical Name: Retapamulin
  • CAS No.: 224452-66-8
  • MF: C30H47NO4S
  • MW:517.76
  • Purity:≥99% or according to customer requested
  • Product Categories: API; Intermediates & Fine Chemicals; Pharmaceuticals; Tetracycline Drugs
  • Test method: HPLC

Description

What is Retapamulin?

Retapamulin is a semi-synthetic pleuromutilin prepared by reacting pleuromutilin tosylate with tropine-3-thiol to give a more hydrophobic analogue with a tertiary amine. This enables formulation as a stable hydrochloride salt. Retapamulin is a broad spectrum antibiotic with no cross resistance to existing antibiotic classes, and is the first pleuromutilin approved for human use. Like all the pleuromutilins, retapamulin inhibits protein synthesis by binding to domain V of 23S rRNA.

Basic information     

Product Name: RETAPAMULIN
Synonyms: RETAPAMULIN;RetapaMulin (SB-275833);(3aS,4R,5S,6S,8R,9R,9aR,10R)-2-(exo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ylsulfanyl)acetic acid 5-hydroxy-4,6,9,10-tetraMethyl-1-oxo-6-vinylperhydro-3a,9-propanocyclopentacycloocten-8-yl ester;RetapaMulin API;tetapaMulin;(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetraMethyl-9-oxotricyclo[5.4.3.0^{1,8}]tetradecan-6-yl 2-{[(1R,3S,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl]sulfanyl}acetate;Rebapamulin;SB-275833
CAS: 224452-66-8
MF: C30H47NO4S
MW: 517.76
EINECS: 639-491-7
Product Categories: Inhibitors; API; Antibiotics
Chemical Structure

RETAPAMULIN            

Chemical Properties     

Boiling point  594.9±50.0 °C(Predicted)
density  1.16±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,2-8°C
pka 14.65±0.70(Predicted)
RETAPAMULIN Uses And Synthesis     

Retapamulin is a semisynthetic pleuromutilin antibiotic. This drug is usually bacteriostatic in action, but may become bactericidal at highed concentrations (when MBC is 1000 times higher than MIC). Retapamulin acts by selectively inhibiting the initiation of protein synthesis in bacteria at the level of bacterial 50S ribosome.

For use in adults and pediatric patients aged 9 months and older for the topical treatment of impetigo (up to 100 cm2 in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) due to Staphylococcus aureus (methicillin-susceptible isolates only) or Streptococcus pyogenes.

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MSDS: MSDS available.

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Email us at: info@maxmedchem.com for more details.

Packaging and Shipping

2023082906101618

2023082906101579

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