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Streptomycin Sulfate

  • Chemical Name:Streptomycin sulfate
  • CAS No.:3810-74-0
  • MF: C21H41N7O16S
  • MW: 679.65
  • Specification: USP|EP|BP
  • Purity:72%,99% or As customer requested
  • Appearance:white to off-white
  • Solubility:>=0.01 g/100 mL at 18 ºC
  • Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; API; Antibiotics; Pesticides; 
  • Test method: HPLC

What is Streptomycin Sulfate?

Streptomycin Sulfate is the sulfate salt form of streptomycin, an aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial property. Streptomycin sulfate binds to the S12 protein of the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis, consequently leading to bacterial cell death.

Streptomycin sulfate Basic information     

Product Name: Streptomycin sulfate
Synonyms: Verstrep; O-2-Deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1->4)-N,N'-bis(aminoiminomethyl)-D-streptamine sulfate; Strep-sol; Streptomyc; Streptomycin 2/3 Sulfate; 2-[(1S,2R,3S,4S,5R,6S)-5-(diaminomethylideneamino)-2-[(2R,3S,4S,5R)-3-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylamino-oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyl-oxolan-2-yl]oxy-3,4,6-trihydroxy-cyclohexyl]guanidine;D-Streptamine, O-2-deoxy-2-(methylamino)-a-L-glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-a-L-lyxofuranosyl-(1->4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3); O-2-Deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-D-Streptamine sulfate (2:3) salt
CAS: 3810-74-0
MF: C21H41N7O16S
MW: 679.65
EINECS: 223-286-0
Product Categories: Intermediates & Fine Chemicals; Oligosaccharides; Pharmaceuticals; API; antibiotic;Antibiotics;Bacteriostatic Alphabetic;Pesticides
Mol File: 3810-74-0.mol

Streptomycin sulfate Chemical Structure

Streptomycin sulfate            

Estreptomicina Chemical Properties     
alpha  -79~-88°(20℃/D)(c=1,H2O)(calculated on the dried basis)
density  1.2302 (rough estimate)
refractive index  -85 ° (C=1, H2O)
storage temp.  2-8°C
solubility  H2O: 0.1 g/mL, clear
form  powder
color  white to off-white
PH pH (100g/l, 25℃) : 4.5~7.0
Water Solubility  >=0.01 g/100 mL at 18 ºC
Merck  14,8826
BRN  3894995
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 3810-74-0
EPA Substance Registry System Streptomycin sulfate (3810-74-0)

Estreptomicina Usage And Synthesis          

Physical and Chemical Properties:

White or white-like powder, odorless, slightly bitter taste, hygroscopic, soluble in water, easily soluble in water and relatively stable, insoluble in ethanol or chloroform, be stable under dry condition, can be sealed from light for more than four years with efficacy unchanged, the aqueous solution can be stored at room temperature pH3~7 for 2 to 4 weeks, in the case of acid, alkali, oxidizing agents, it is easily damaged and lose effect.    

Clinical application:

This product is effective against Gram-positive bacteria and gram-negative bacteria. But it is less effective than penicillin G in treating Gram-positive bacteria such as Streptococcus pneumoniae bacteria, and has no effects on Rickettsia, protozoa, viruses and fungi; It has a good effect on treating Mycobacterium tuberculosis and many kinds of gram-negative bacteria such as Escherichia.coli, Brucella, gas, influenza bacillus, Shigella, and Yersinia pestis. The main clinical application is used for the treatment of Mycobacterium tuberculosis induced diseases cuh as tuberculosis, bone tuberculosis, lymphatic, intestinal tuberculosis, tuberculous meningitis and meningitis caused by susceptible strains, pneumonia, sepsis, empyema, pleurisy, peritonitis, etc., It can also be used for treating infection of urinary tract and respiration system caused by susceptible strains.    

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

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