The effects and side effects of 5HTP

The effects of 5HTP

In alternative medicine, 5HTP is believed to help treat the following conditions:

a: depression

b: Anxiety

c: Insomnia

d: Fibromyalgia

e: Migraine

f: lose weight

Here I’ll introduce the details of those Effects:

1. 5 hydroxytryptophan can prevent depression

Some small clinical trials have found that serotonin is as effective as antidepressants. For example, in a six-week clinical trial, 63 people took 5-HTP (three times a day, 100 mg each time) or antidepressants (three times a day, 50 mg each time). 5-HTP was found to be as effective as antidepressants, with fewer side effects.

However, a 2002 systematic review of studies published between 1966 and 2000 found that only one of 108 studies met quality standards.

This small study did meet quality standards and found that 5-HTP was more effective than placebo in relieving depression.

2. Migraine

Some studies have shown that serotonin may prevent migraines and reduce the frequency and severity of migraines, but a large number of randomized controlled trials are still needed.

In one study, 124 people took 5-HTP (600 mg/day) or methylsergide. After 6 months, 5-HTP was found to be as effective as methysergide in reducing the severity and duration of migraine.

Another study looked at serotonin or propranolol for 4 months. Both treatments significantly reduced the incidence of migraine. However, the propranolol group performed better, reducing the duration of the attack and the number of analgesics used to treat the attack.

3. Fibromyalgia

Fibromyalgia is a chronic disease characterized by fatigue, extensive pain in muscles, ligaments and tendons, and multiple tender points.

A double-blind, placebo-controlled study looked at serotonin or placebo in 50 fibromyalgia patients. After four weeks, pain, stiffness, anxiety, fatigue and sleep have all improved. The side effects are mild and short-lived.

4. Insomnia

Serotonin is converted into melatonin, a hormone needed to regulate the sleep-wake cycle. Because serotonin is thought to increase serotonin levels, it may increase melatonin and help normalize sleep patterns.

The side effects of 5HTP

5-HTP is probably safe and is taken by mouth when appropriate. 5-HTP has been used safely, with a dose of up to 400 mg per day for up to one year. However, some people who take it have developed a condition called eosinophilia-myalgia syndrome (EMS), which is a serious condition that includes extreme muscle tenderness (myalgia) and blood abnormalities (Eosinophilia). Some people think that EMS may be caused by accidental ingredients or contaminants in certain 5-HTP products. However, there is not enough scientific evidence to know whether EMS is caused by 5-HTP, pollutants or other factors. Before learning more, 5-HTP should be used with caution.

Other potential side effects of 5-HTP include heartburn, stomach pain, nausea, vomiting, diarrhea, drowsiness, sexual problems, and muscle problems.

5-HTP is probably unsafe when taken orally. A daily dose of 6-10 grams is associated with severe stomach problems and muscle cramps.

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