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TRICHOSTATIN A
- Chemical Name:TRICHOSTATIN A
- CAS No.:58880-19-6
- MF: C17H22N2O3
- MW: 302.37
- Specification: USP|EP|BP
- Purity:98%,99% or As customer requested
- Chemical Properties:Off-white lyophilized solid\
- Solubility：ethanol: 1 mg/mL
- Product Categories: Inhibitors;antibiotic;Anti Cancer Research;API
- Test method: HPLC
Description
Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces.
Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth.
This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals.
TRICHOSTATIN A Basic information
| Product Name: | TRICHOSTATIN A |
| Synonyms: | 7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide;7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID;Trichostatin A from Streptomyces platensis;[r-(e,e)]-7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide;7-(4-DIMETHYLAMINOPHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-HEPTA-2,4-DIENAMIDE;TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide |
| CAS: | 58880-19-6 |
| MF: | C17H22N2O3 |
| MW: | 302.37 |
| EINECS: | 611-758-2 |
| Product Categories: | Inhibitors; antibiotic; Anti Cancer Research; Inhibitor; API |
TRICHOSTATIN A Chemical Structure
Trichostatin antibiotic Chemical Properties
| Melting point | 140-143℃ |
| alpha | D20.5 +62.8° ±1.1° (c = 1.007 in ethanol) |
| density | 1.139 |
| refractive index | 136 ° (C=0.3, MeOH) |
| storage temp. | −20°C |
| solubility | ethanol: 1 mg/mL |
| form | Off-white lyophilized solid |
| pka | 8.93±0.23(Predicted) |
| Merck | 14,9649 |
| InChIKey | ZWGICMNKJBUOHG-RCXLNATQSA-N |
Trichostatin antibiotic Usage And Synthesis
| Chemical Properties | Solid |
| Uses | Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells. |
MSDS: MSDS available.
COA: COA can be available if you send us inquiry.
Email us at: info@maxmedchem.com for more details.
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