Author: Site Editor Publish Time: 2022-12-14 Origin: Site
Nonsteroidal anti-inflammatory drugs (NSAIDs) include diclofenac and aceclofenac. Diclofenac is recommended for the treatment of inflammatory and painful rheumatic and nonrheumatic conditions like rheumatoid arthritis,osteoarthritis,ankylosing spondylitis,tendinitis,and bursitis.It is also recommended for other inflammatory or painful conditions like dysmenorrhea,back pain,sciatica,and postoperative pain.It can be administered orally,rectally,or intramuscularly in a number of different ways.Diclofenac is one of the few NSAIDs that is considered to be the "first choice" for treating both acute and ongoing conditions that are painful and inflammatory.
Most people think that diclofenac's inhibition of prostaglandin synthesis is responsible for its anti-inflammatory and most of its other pharmacological effects.In vitro and in vivo,diclofenac is a potent inhibitor of cyclooxygenase,reducing the synthesis of prostaglandins,prostacyclin,and thromboxane products.Aceclofenac,on the other hand,is a phenyl acetic acid derivative that can be taken orally and affects a variety of inflammatory mediators.Aceclofenac reduces pain intensity and morning stiffness in rheumatoid arthritis patients,as well as improves spinal mobility in ankylosing spondylitis patients,and it provides symptomatic relief for a variety of painful conditions like joint inflammation.After conventional oral,rectal,or intramuscular administration, diclofenac is rapidly and effectively absorbed.Plasma concentrations peak 10-30 minutes after intramuscular administration.Compared to aceclofenac,which is also rapidly and completely absorbed after oral administration,with peak plasma concentrations (Cmax) being reached 1.25-3 h after ingestion,the enteric-coated formulation's mean peak plasma concentrations of unchanged diclofenac are 0.7-1.5 mg after a single 50 mg dose.This is delayed by food to 2.5-12 h. The drug is highly protein-bound (>99 percent) in plasma,and the volume of distribution (Vd) is approximately 25 L.Diclofenac's tolerance profile is well-established.The most common adverse effects,followed by minor symptoms in the central nervous system (CNS) and allergic or local reactions,are gastrointestinal (GI) problems and withdrawal of the medication in 1.5-2% of patients. However, aceclofenac-related adverse events (AEs) tend to be mild, reversible,and primarily gastrointestinal in nature.Dyspepsia and abdominal pain account for less than 5% of cases.Aceclofenac has been associated withdizziness,vertigo,pruritus,a rash,and dermatitis,but these side effects are uncommon (less than 5%).Diclofenac can be started at 150 mg per day in two or three divided doses with food in conventional or enteric-coated tablets.Most patients can keep therapeutic control at 100 mg per day.
Aceclofenac powder,in contrast to diclofenac sodium,has a quicker onset of pain relief and a longer duration of action in the immediate postoperative period, making it particularly useful for individuals with gastritis and acid peptic disease.Although both nonsteroidal anti-inflammatory drugs (NSAIDs) provide better pain relief for patients who have had impacted third molar extractions,Aceclofenac is more effective than diclofenac sodium.Diclofenac sodium is preferred.