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Chlorpheniramine Maleate (113-92-8) C20H23ClN2O4

  • Chemical Name: Chlorpheniramine maleate
  • CAS No.: 113-92-8
  • MF:C20H23ClN2O4
  • MW: 390.86
  • Specification: USP|EP|BP
  • Purity:98% or As customer requested
  • Color: white crystalline solid or white powder
  • Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Antagonists;Neurotransmitters
  • Solubility:Water soluble.
  • Test method: HPLC 
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Chlorpheniramine Maleate General Description   


Chlorpheniramine maleate, (±)2-[p-chloro-α-[2-dimethylamino)ethyl]benzyl]pyridine bimaleate (Chlor-Trimeton), is a white crystallinepowder that is soluble in water (1:3.4), in alcohol(1:10), and in chloroform (1:10). It has a pKa of 9.2, and anaqueous solution has a pH between 4 and 5. Chlorination ofpheniramine in the para position of the phenyl ring increasespotency 10-fold with no appreciable change in toxicity.Most of the antihistaminic activity resides with thedextro isomer (see under “Dexchlorpheniramine Maleate” ).The usual dose is 2 to 4 mg 3 or 4 times a day. It has a halflifeof 12 to 15 hours.

Piriton Basic information  
Product Name: Chlorpheniramine maleate
Synonyms: 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethy-laminopropanebimaleate;1-Parachlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate; 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1); 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1); Chlorophenamine; Chlorprophenpyridamine maleate; Cloropiril; Histadur
CAS: 113-92-8
MF: C20H23ClN2O4
MW: 390.86
EINECS: 204-037-5
Product Categories: API; TELDRIN; Intermediates & Fine Chemicals; Pharmaceuticals; Antagonists; Histaminergics; Neurotransmitters
Mol File: 113-92-8.mol

Chlorphenamine Maleate Chemical Structure

Chlorpheniramine maleate            

Antagonate Chemical Properties

         

Melting point  130-135 °C (lit.)
alpha  -1~+1°(D/20℃)(c=5,DMF)
density  1.1984 (rough estimate)
refractive index  1.6800 (estimate)
Fp  9℃
storage temp.  -20°C Freezer
solubility  Freely soluble in water, soluble in ethanol (96 per cent)
form  neat
PH 4.0~5.5 (10g/l, 25℃)
Water Solubility  1-5 g/100 mL at 21 ºC
Merck  14,2180
InChIKey DBAKFASWICGISY-BTJKTKAUSA-N
EPA Substance Registry System Chlorpheniramine maleate (113-92-8)

Chlorpheniramine Maleate Usage And Synthesis



Chemical Properties White Solid
Uses An antagonist of the histamine H1-receptor
Antihistaminic
General Description

Chlorpheniraminemaleate, (±)2-[p-chloro-α-[2-dimethylamino)ethyl]benzyl]pyridine bimaleate (Chlor-Trimeton), is a white crystallinepowder that is soluble in water (1:3.4), in alcohol(1:10), and in chloroform (1:10). It has a pKa of 9.2, and anaqueous solution has a pH between 4 and 5. Chlorination ofpheniramine in the para position of the phenyl ring increasespotency 10-fold with no appreciable change in toxicity.Most of the antihistaminic activity resides with thedextro isomer (see under “Dexchlorpheniramine Maleate” ).The usual dose is 2 to 4 mg 3 or 4 times a day. It has a halflifeof 12 to 15 hours.
Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.
Air & Water Reactions Water soluble.

MSDS: MSDS available


COA: COA can be available if you send us inquiry.


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