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D Glucosamine Hydrochloride

  • Product Name:Pharmaceuticals Grade D-Glucosamine hydrochloride
  • CAS No.: 66-84-2
  • MF: C6H14ClNO5
  • MW: 215.63
  • Specification: USP|EP|BP
  • Purity: 98% or as customer requested
  • Chemical Properties:White Solid
  • Product Categories: pharmaceutical intermediate; phytochemical; Food & Flavor Additives; Amines; Carbohydrates & Derivatives; standardized herbal extract
  • Form: crystalline
  • Test method: HPLC
  • Water Solubility:soluble

What is D Glucosamine Hydrochloride?

Individuals take d-glucosamine hydrochloride by mouth for osteoarthritis, rheumatoid joint inflammation, glaucoma, a jaw problem called temporomandibular jumble (TMD), joint torment, back torment, and weight reduction.

Glucosamine hydrochloride is applied to the skin in blend with chondroitin sulfate, shark ligament, and camphor for osteoarthritis.

D glucosamine hydrochloride is utilized parenterally and present moment to lessen osteoarthritis side effects.

D Glucosamine Hydrochloride Basic information  

Product Name: D-Glucosamine hydrochloride
CAS: 66-84-2
MF: C6H14ClNO5
MW: 215.63
EINECS: 200-638-1
Product Categories: Anilines, Aromatic Amines and Nitro Compounds; Inhibitors; Aminosugars; Biochemistry; Other APIs; Food additives; Glucose; Sugars; Nutritional Supplements; Dextrins,Sugar & Carbohydrates; Biological and chemical; chemical reagent; pharmaceutical intermediate; phytochemical; Food & Flavor Additives; Amines; Carbohydrates & Derivatives; standardized herbal extract
Mol File: 66-84-2.mol

D Glucosamine Hcl Chemical Structure

D-Glucosamine hydrochloride            

2 Amino D Glucose Hydrochloride Chemical Properties

Melting point  190-194 °C (dec.)(lit.)
alpha  72.5 º (c=2, H2O, 5hrs.)
refractive index  72 ° (C=1, H2O)
storage temp.  Store at RT.
solubility  H2O: 0.1 g/mL, clear, colorless
form  crystalline
Water Solubility  soluble
Merck  14,4458
BRN  4157370
Stability: Stable. Incompatible with strong oxidizing agents. Combustible.
CAS DataBase Reference 66-84-2(CAS DataBase Reference)
EPA Substance Registry System D-Glucose, 2-amino-2-deoxy-, hydrochloride (66-84-2)
D Glucosamine Hydrochloride Usage And Synthesis

Chemical Properties white powder
Uses Novel application of D-Glucosamine hydrochloride to prepare medical agent for treating vertigo. Found in chitin, in mucoproteins, and in mucopolysaccharides. Antiarthritic. Recent studies show that its chondroprotective activity is related to its antiapoptic properties.
Uses glucosamine hydrochloride (glucosamine HCl) is used to adjust the pH of a formulation. It also has anti-static and hair-conditioning properties.
Purification Methods Crystallise the hydrochloride from 3M HCl, water, and finally water/EtOH/acetone as for galactosamine hydrochloride. [Purchase & Braun Org Synth 26 36 1946, Stacey & Webber Methods in Carbohydrate Chemistry I 228 1962, Academic Press.] The salt has also been purified by dissolving in the minimum volume of boiling H2O (charcoal), filtering and adding a large excess of 95% EtOH (~4 volumes) and stirring vigorously for several hours. Collect the crystals after 4-6hours to give  anomer which mutarotates ] D +100o to +72o (equilibrium, c 1, H2O). A large amount of the -anomer stays in solution. This can be precipitated from the filtrate by adding excess Et2O. The mixture of -plus -anomers has [] D +68.8o (c 4.75, H2O, mutarotating to +70.1o)[Leaback Biochemical Preparations 10 118 1963]. Note that if Et2NH is used instead of Et3N, conversion to the -anomer can be complete (see above). [Stacey et al. Methods in Carbohydrate Chemistry I 3061962, Academic Press; Beilstein 4 IV 2018.]

D Glucosamine Hydrochloride Benefits:

Elevated cholesterol. Early examination recommends that d glucosamine hydrochloride doesn't influence cholesterol or fatty oil levels in individuals with elevated cholesterol.

Bone and joint infection called Kashin-Beck illness. Early proof shows that taking glucosamine hydrochloride alongside chondroitin sulfate diminishes torment and works on actual capability in grown-ups with a bone and joint issue called Kashin-Beck sickness. The impacts of glucosamine sulfate on side effects of Kashin-Beck infection are blended when the enhancement is taken as a solitary specialist.

Knee torment. There is some early proof that d glucosamine hydrochloride could give a help with discomfort to individuals who have successive knee torment because of joint injury.

Osteoarthritis. There is clashing proof about the adequacy of d-glucosamine hydrochloride for osteoarthritis. The majority of the proof supporting the utilization of glucosamine hydrochloride comes from investigations of a specific item (CosaminDS, Nutramax Laboratories). 

The impacts of taking glucosamine hydrochloride alongside just chondroitin sulfate are blended. Some proof shows that taking a particular item (Droglican, Bioiberica S.A., Barcelona, Spain) containing glucosamine hydrochloride and chondroitin sulfate decreases torment in grown-ups with knee osteoarthritis. In any case, other examination shows that equations containing glucosamine hydrochloride and chondroitin sulfate are not successful at diminishing torment in patients with knee osteoarthritis.

Most exploration recommends that taking glucosamine hydrochloride alone doesn't diminish torment in individuals with osteoarthritis of the knee.

More examination has been finished on glucosamine sulfate (see separate posting) than on glucosamine hydrochloride. There is some felt that d glucosamine hydrochloride might be more compelling than glucosamine hydrochloride for osteoarthritis. Most exploration looking at the two types of glucosamine showed no distinction. Be that as it may, a few scientists have scrutinized the nature of a portion of these investigations.

Rheumatoid joint inflammation. Early examination shows that taking a particular d-glucosamine hydrochloride item (Rohto Pharmaceuticals Co.) in mix with professionally prescribed clinical medicines lessens torment contrasted with a sugar pill. Nonetheless, this item doesn't appear to diminish aggravation or lessen the quantity of agonizing or enlarged joints.

Jaw torment (temporomandibular jumble). Early exploration shows that taking a blend of d-glucosamine hydrochloride, chondroitin sulfate, and calcium ascorbate two times day to day diminishes joint enlarging and torment, as well as commotion made at the jaw joint, in individuals with temporomandibular jumble.

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

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