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D-Glucosamine Hydrochloride (66-84-2) C6H14ClNO5

  • Product Name:Pharmaceuticals Grade D-Glucosamine hydrochloride
  • CAS No.: 66-84-2
  • MF: C6H14ClNO5
  • MW: 215.63
  • Specification: USP|EP|BP
  • Purity: 98% or as customer requested
  • Chemical Properties:White Solid
  • Product Categories: pharmaceutical intermediate; phytochemical; Food & Flavor Additives; Amines; Carbohydrates & Derivatives; standardized herbal extract
  • Form: crystalline
  • Test method: HPLC
  • Water Solubility:soluble

D Glucosamine Hydrochloride Basic information  

Product Name: D-Glucosamine hydrochloride
CAS: 66-84-2
MF: C6H14ClNO5
MW: 215.63
EINECS: 200-638-1
Product Categories: Anilines, Aromatic Amines and Nitro Compounds; Inhibitors; Aminosugars; Biochemistry; Other APIs; Food additives; Glucose; Sugars; Nutritional Supplements; Dextrins,Sugar & Carbohydrates; Biological and chemical; chemical reagent; pharmaceutical intermediate; phytochemical; Food & Flavor Additives; Amines; Carbohydrates & Derivatives; standardized herbal extract
Mol File: 66-84-2.mol

D Glucosamine Hcl Chemical Structure

D-Glucosamine hydrochloride            

2 Amino D Glucose Hydrochloride Chemical Properties

Melting point  190-194 °C (dec.)(lit.)
alpha  72.5 º (c=2, H2O, 5hrs.)
refractive index  72 ° (C=1, H2O)
storage temp.  Store at RT.
solubility  H2O: 0.1 g/mL, clear, colorless
form  crystalline
Water Solubility  soluble
Merck  14,4458
BRN  4157370
Stability: Stable. Incompatible with strong oxidizing agents. Combustible.
CAS DataBase Reference 66-84-2(CAS DataBase Reference)
EPA Substance Registry System D-Glucose, 2-amino-2-deoxy-, hydrochloride (66-84-2)
D Glucosamine Hydrochloride Usage And Synthesis

Chemical Properties white powder
Uses Novel application of D-Glucosamine hydrochloride to prepare medical agent for treating vertigo. Found in chitin, in mucoproteins, and in mucopolysaccharides. Antiarthritic. Recent studies show that its chondroprotective activity is related to its antiapoptic properties.
Uses glucosamine hydrochloride (glucosamine HCl) is used to adjust the pH of a formulation. It also has anti-static and hair-conditioning properties.
Purification Methods Crystallise the hydrochloride from 3M HCl, water, and finally water/EtOH/acetone as for galactosamine hydrochloride. [Purchase & Braun Org Synth 26 36 1946, Stacey & Webber Methods in Carbohydrate Chemistry I 228 1962, Academic Press.] The salt has also been purified by dissolving in the minimum volume of boiling H2O (charcoal), filtering and adding a large excess of 95% EtOH (~4 volumes) and stirring vigorously for several hours. Collect the crystals after 4-6hours to give  anomer which mutarotates ] D +100o to +72o (equilibrium, c 1, H2O). A large amount of the -anomer stays in solution. This can be precipitated from the filtrate by adding excess Et2O. The mixture of -plus -anomers has [] D +68.8o (c 4.75, H2O, mutarotating to +70.1o)[Leaback Biochemical Preparations 10 118 1963]. Note that if Et2NH is used instead of Et3N, conversion to the -anomer can be complete (see above). [Stacey et al. Methods in Carbohydrate Chemistry I 3061962, Academic Press; Beilstein 4 IV 2018.]

MSDS: MSDS available

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