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Diphenhydramine HCL

  • Chemical Name: Diphenhydramine Hydrochloride
  • CAS No.: 147-24-0
  • MF:C17H22ClNO
  • MW: 291.82
  • Specification: USP|EP|BP
  • Purity:99% or As customer requested
  • Color: White or almost white, crystalline powder.
  • Categories: Pharmaceutical intermediates;Anilines, Aromatic Amines and Nitro Compounds;API intermediates;Amines;Aromatics;Intermediates & Fine Chemicals
  • Solubility:Water soluble. Aqueous solutions are acidic.
  • Test method: HPLC

What is Diphenhydramine HCL?

Diphenhydramine HCL(DPH) is an allergy med drug principally used to treat allergies. It can likewise be utilized for a sleeping disorder, side effects of the normal cold, quake in parkinsonism, and queasiness.

It is taken by mouth, infused into a vein, infused into a muscle, or applied to the skin. Maximal impact is ordinarily something like two hours after a portion, and impacts can keep going for as long as seven hours.

Diphenhydramine hcl powder is utilized to assuage red, aggravated, irritated, watery eyes; wheezing; and runny nose brought about by roughage fever, sensitivities, or the normal virus. Diphenhydramine hcl is additionally used to assuage hack brought about by minor throat or aviation route aggravation. Diphenhydramine hcl powder is additionally used to forestall and treat movement affliction, and to treat sleep deprivation (trouble nodding off or staying unconscious).

Diphenhydramine hcl is likewise used to control strange developments in individuals who have beginning phase parkinsonian condition (an issue of the sensory system that causes hardships with development, muscle control, and equilibrium) or who are encountering development issues as a symptom of a medicine.

Diphenhydramine Hydrochloride1

Diphenhydramine Hcl Basic information  

Product Name: Diphenhydramine Hydrochloride
Synonyms: 2-(diphenylmethoxy)-n,n-dimethyl-ethanaminhydrochloride;2-(diphenylmethoxy)-n,n-dimethyl-ethylaminhydrochloride;Actifed;alpha-Hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochloride;alpha-hydroxydiphenylmethane-beta-dimethylaminoethyletherhydrochloride;Ambenyl;BAX;Benacine
CAS: 147-24-0
MF: C17H22ClNO
MW: 291.82
EINECS: 205-687-2
Product Categories: On the central nervous activity inhibition of sedative hypnotic effect; API; Histamine receptor; BENADRIL; Other APIs; Pharmaceutical intermediates; Anilines, Aromatic Amines and Nitro Compounds; API intermediates; Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals
Mol File: 147-24-0.mol

Dimedrol Chemical Structure

Diphenhydramine Hydrochloride            

Cathejell Chemical Properties


Melting point  168-172 °C
Boiling point  163-167 °C(Press: 3 Torr)
density  1.0489 (rough estimate)
refractive index  1.5800 (estimate)
Fp  9℃
storage temp.  Desiccate at RT
solubility  Very soluble in water, freely soluble in alcohol.
form  Crystalline Powder or Adhering Crystals
color  White
PH pH(100g/L, 25℃) 4.0~5.5
Water Solubility  1000 g/L
Sensitive  Light Sensitive
Merck  14,3309
Stability: Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents.
CAS DataBase Reference 147-24-0(CAS DataBase Reference)
NIST Chemistry Reference diphenhydramine hydrochloride(147-24-0)
EPA Substance Registry System Diphenhydramine hydrochloride (147-24-0)

Diphenhydramine Hydrochloride Usage And Synthesis

Indications and Usage Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.
  1. antihistaminic: For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.

  2. Motion Sickness: For active treatment of motion sickness.

  3. Antiparkinsonism: For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.

  1. Use in Neonates or Premature Infants: This drug should not be used in neonates or premature infants.

  2. Use in Nursing Mothers: Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.

  3. Use as a Local Anesthetic: Because of the risk of local necrosis, this drug should not be used as a local anesthetic.

  4. Antihistamines are also contraindicated in the following conditions: Hyper sensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure.

Chemical Properties White or almost white, crystalline powder.


Take the tablet, capsule, or liquid form by mouth with or without food. Measure liquid forms of this drug using a special measuring device/ ladle. Don't use a ménage ladle because you may not get the correctdose.However, you don't need to measure the cure, If you have a single- cure form of this drug( similar as a single- use whoosh).

The fleetly- dissolving tablet or strip should be allowed to dissolve on the lingo and also swallowed, with or without water. The chewable tablets should be masticated completely before being swallowed.

The lozenge is grounded on your age, medical condition, and response to treatment. There are numerous brands and forms of diphenhydramine hcl available. Read the dosing instructions precisely for each product because the quantum of diphenhydramine may be different between products. Don't increase your cure or take this drug more frequently than directed.

To help stir sickness, take your cure 30 twinkles before starting exertion similar as trip. To help you sleep, take your cure about 30 twinkles beforebedtime.However, communicate your croaker , If you continue to have difficulty sleeping for longer than 2 weeks.

Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine hcl is categorized as an antihistaminic; sedative, hypnotic.
antihistamine, sedative, treatment of allergic
A histamine H1-receptor antagonist.
H1-Histamine receptor antagonist. Antihistaminic; sedative, hypnotic
Brand name Benadryl (Parke-Davis).
Therapeutic Function Antihistaminic
General Description White or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6.
Air & Water Reactions Water soluble. Aqueous solutions are acidic.

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

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