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Parecoxib Sodium
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  2. Parecoxib Sodium

PARECOXIB SODIUM

Product Name: Chemical & Pharmaceutical Grade PARECOXIB SODIUM

CAS No.: 198470-85-8
Specification: 98%
MF: C19H17N2NaO4S
Appearance: White Powder
 
 
Category:

Description

Parecoxib Sodium is a water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation. 

Product Name: PARECOXIB SODIUM
Synonyms: sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide;
sodium salt; parecoxib sodium salt; Dynastat;
CAS: 198470-85-8
MF: C19H17N2NaO4S
MW: 392.40405
EINECS: 813-689-5
Product Categories:

Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals
Mol File: 198470-85-8.mol

  

Parecoxib Sodium Chemical Formula

1            

Parecoxib Sodium Salt Chemical Properties

Melting point: 273-275°C
storage temp. Refrigerator

PARECOXIB SODIUM Usage And Synthesis

Chemical Properties: White Solid
Uses Anti-inflammatory, analgesic.

DYNASTAT Pfizer Functions

2

  • Parecoxib Sodium is indicated for relief of the signs and symptoms of osteoarthritis.

  • For relief of the signs and symptoms of rheumatoid arthritis in adults.

  • For relief of the signs and symptoms of particular or poly articular course Juvenile Rheumatoid Arthritis (JRA) in patients.

  • For the management of acute pain in adults. 

  • For the treatment of primary dysmenorrhea.

  • For the acute treatment of migrain attacks with or without aura in adults.

  • The safety and effectiveness of Parecoxib have not been established for cluster headache, which is present in an older, predominantly male, population.

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