Penicillin G Sodium Salt

Description

Penicillin G Sodium Salt is the sodium salt form of benzylpenicillin, a semi-synthetic, broad-spectrum penicillin antibiotic with bactericidal activity. Benzylpenicillin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall.

Inactivation of Penicillin G Sodium Salt interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Penicillin G sodium salt Basic information

Product Name:	Penicillin G sodium salt
Synonyms:	benzyl penicillinic acid sodium salt; sodium penicillinii;BENZYL PENICILLIN SODIUM;BENZYLPENICILLIN SODIUM SALT
CAS:	69-57-8
MF:	C16H17N2NaO4S
MW:	356.37
EINECS:	200-710-2
Product Categories:	Pharmaceutical raw chemicals; API; antibiotic; Biochemistry

Benzylpenicillin sodium Chemical Structure

Penicillin G sodium salt

Crystapen Chemical Properties

Melting point	209-212°C
alpha	D24.8 +301° (c = 2.0 in water)
density	1.41
refractive index	300 ° (C=2, H2O)
storage temp.	2-8°C
solubility	H₂O: 100 mg/mL Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for extended periods. Solutions are stable at 37°C for 3 days.
form	powder
color	colorless or white
PH	5.5-7.5 (3% in H2O)
Water Solubility	5-10 g/100 mL at 25 ºC
Merck	14,7094
BRN	3834217
Stability:	Stability Stable, but incompatible with a wide variety of materials, including acids, oxidizing agents, heavy metals, alcohols, glycerol, thiomersal, many surface-active agents, alkalies, peroxides, reducing agents, lanolin, glycol, sugars, amines, iodine, iodides, thiols. Hygroscopic.

Crystapen Usage And Synthesis

Chemical Properties	White powder
Uses	Sodium salt of Penicillin G, an antibacterial, antimicrobial medication. Used in the treatment of pneumococcus and streptococcus bacterial infections.
World Health Organization (WHO)	Penicillin is listed separately in the WHO Model List of Essential Drugs.
General Description	White to slightly yellow crystalline powder with a faint odor. pH (10% solution) 5.5-7.5.
Air & Water Reactions	Water soluble.