RIFAMPIN QUINONE

Description

RIFAMPIN QUINONE 50 MG Basic information

In this study we have found that Rifampicin Quinone in arrangement goes through a synthetic transformation to Rifampicin that is temperature subordinate. This change happens in physiologically important temperatures (30−50 °C) and time scales (24−120 h) and was checked utilizing HPLC and LC-MS techniques.

Furthermore, the transformation of Rifampicin Quinone to Rifampicin brings about an expansion in antimicrobial action. We accept that our own is the main review revealing the unsteadiness of Rifampicin Quinone, and this flimsiness in arrangement at these temperatures and time scales raises worries for its utilization as a norm in quality testing utilizing fluid chromatography techniques and in investigations of the impact of Rifampicin Quinone on AMR.

Product Name:	RIFAMPIN QUINONE (50 MG)
Synonyms:	Reaxys ID: 1069552;Rifampicin EP Impurity A (Rifampicin Quinone);Rifampicin ImpuritⅢ :rifampicin quinone;Rifampin Impurity A(EP);Rifampicin Impurity 1（Rifampicin EP Impurity A）;RIFAMPIN QUINONE (50 MG);dehydrorifampicin;Nsc145633
CAS:	13983-13-6
MF:	C43H56N4O12
MW:	820.92
Product Categories:	Intermediates & Fine Chemicals; Metabolites & Impurities; Heterocycles; Pharmaceuticals

RIFAMPIN QUINONE 50 MG Chemical Structure

RIFAMPIN QUINONE (50 MG)

RIFAMPIN QUINONE Certificate of Analysis

Item	Standard	Test Results
Identification	A.H-NMR:Comply with the structure	Complies
	B.LC-MS:Comply with the structure	Complies
	C.The IR spectrum of sample should be identical with that of reference standard.	Complies
	D.HPLC-ESI-MSThe retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.	Complies
Crystallinity	meets the requirements.	Complies
Loss on drying	≤2.0%	0.19%
Heavy metals	≤10 ppm	<10ppm
Water	≤1.0%	0.1%
Sulphated ash	≤0.5% determined on 1.0 g.	0.009%
Residue on ignition	≤0.1%	0.03%
Related Substances	Unspecified impurities: for each impurity ≤0.10%	<0.10%
Related Substances	Total Impurity ≤0.5%	0.18%
Purity	≥99.0%	99.7%
Assay	99.0%~101.0% (anhydrous substance).	99.8%
Microbiological Analysis	Total plate count ≤1000cfu/g	Complies
	Yeast & Moulds ≤100cfu/g	Complies
	E. Coli. Absent	Negative
	Salmonella Absent	Negative
	S.aureus Absent	Negative
Storage	Preserve in well-closed,light-resistant and airtight containers.	Complies