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Rosiglitazone Maleate (155141-29-0) C22H23N3O7S

  • Chemical Name:Rosiglitazone maleate
  • CAS No.:155141-29-0
  • MF: C22H23N3O7S
  • MW:473.5Specification: USP|EP|BP
  • Purity: >95% or As customer requested
  • Color: White powder
  • Product Categories: API; Inhibitor; Antidiabetic; Intermediates & Fine Chemicals; Pharmaceuticals; APIs;
  • Test method: HPLC
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Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.(Source: NCI Thesaurus (NCIt))

Rosiglitazone maleate Basic information   
Product Name: Rosiglitazone maleate
Synonyms: ROSIGLITAZONE MALEATE; Rosiglitazone Tartrate; 
CAS: 155141-29-0
MF: C22H23N3O7S
MW: 473.5
EINECS: 642-163-6
Product Categories: API; Inhibitor; Antidiabetic; Intermediates & Fine Chemicals; Pharmaceuticals; API's; Active Pharmaceutical Ingredients

Rosiglitazone maleate Chemical Structure

Rosiglitazone maleate            

Avandia Chemical Properties    
Melting point  235-240°C
storage temp.  -20°C Freezer
pka 6.1; 6.8(at 25℃)
form  White powder
InChIKey HCDYSWMAMRPMST-NTCAYCPXSA-N

Avandamet Usage And Synthesis


Rosiglitazone maleate, belongs to a novel class of thiazolidine diones launched for the treatment of non-insulin-dependent diabetes mellitus (NIDDM), a disease characterized by a pancreatic β-cell defect and insulin resistance in the liver and peripheral tissues.


Chemical Properties White To Off-White Solid


Uses


Insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- γ).
Thiazole alkanes antidiabetic drug


MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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