Tetracycline Hydrochloride

Description

Tetracycline Hydrochloride is the hydrochloride salt of tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens.

In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally fluorescing tetracycline binds to newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.

Tetracycline hydrochloride Basic information

Product Name:	Tetracycline hydrochloride
Synonyms:	alatet; amycin,hydrochloride; artomycin;cancycline-250; cefracyclinetablets; chlorhydratedetetracycline; chlorowodorkutetracykliny; cyclopar
CAS:	64-75-5
MF:	C22H25ClN2O8
MW:	480.9
EINECS:	200-593-8
Product Categories:	Amines; Chiral Reagents; Antibiotic Explorer; Intermediates & Fine Chemicals; Pharmaceuticals;Antibacterial ;Antibiotics; Tetracyclines Antibiotics; Active Pharmaceutical Ingredients; API
Mol File:	64-75-5.mol

Tetracycline hcl Chemical Structure

Tetracycline hydrochloride

Supramycin Chemical Properties

Melting point	220-223 °C(lit.)
alpha	-252 º (c=0.5, H2O)
refractive index	-253 ° (C=0.5, 0.1mol/L HCl)
storage temp.	2-8°C
solubility	H₂O: 10 mg/mL as a stock solution. Stock solutions should be filtered sterilized and stored at −20°C. Stable at 37°C for 4 days.
form	powder
color	faint yellow to yellow
PH	pH(10g/l, 25℃) : 1.8～3.0
optical activity	[α]/D -255 to 240° (Specific rotation )
Water Solubility	50 g/L
Sensitive	Air & Light Sensitive
Merck	14,9196
BRN	3844873
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	XMEVHPAGJVLHIG-FMZCEJRJSA-N
CAS DataBase Reference	64-75-5(CAS DataBase Reference)
EPA Substance Registry System	Tetracycline hydrochloride (64-75-5)

Sumycin Usage And Synthesis

Chemical Properties	Yellow crystalline powder
Uses	Antibiotic substance produced by Streptomyces spp. Antiamebic; antibacterial; antirickettsial.
Uses	Tetracycline hydrochloride is a salt prepared from tetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Tetracycline hydrochloride has broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-unit,s blocking protein synthesis.
General Description	Crystals or fine bright yellow powder. pH of 2% aqueous solution: 2.1 – 2.3.
Air & Water Reactions	Water soluble.
Reactivity Profile	Tetracycline hydrochloride is acidic. Reacts with strong oxidizing agents .
Fire Hazard	Flash point data concerning Tetracycline hydrochloride are not available, however, Tetracycline hydrochloride is probably combustible.
Safety Profile	Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects: change in taste function. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also TETRACYCLINE.