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Tiotropium Bromide

  • Chemical Name:Tiotropium bromide
  • CAS No.:136310-93-5
  • MF: C19H22BrNO4S2
  • MW:472.42
  • Purity:≥98% or according to customer requested
  • Color: White powder
  • Product Categories: Pharmaceutical intermediate;Bulk Drug Intermediates;Asthma drugs;APIs
  • Test method: HPLC

What is Tiotropium Bromide?

Tiotropium Bromide is the bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a muscarinic receptor antagonist, with bronchodilating activity. Although it does not display selectivity for specific muscarinic receptors, on topical application, tiotropium bromide acts mainly on M3 muscarinic receptors located on smooth muscle cells and submucosal glands, preventing smooth muscle contraction and mucus secretion, thus producing a bronchodilatory effect.

Product Name: Tiotropium bromide
Synonyms: Tiotropium;  bromide Tiotropium; Spiriva
CAS: 136310-93-5
MF: C19H22BrNO4S2
MW: 472.42
EINECS: 680-665-7
Product Categories: Pharmaceutical intermediate;Bulk Drug Intermediates;Asthma drugs;APIs
Chemical Structure

Tiotropium bromide            

Chemical Properties
Melting point 218-2200C
storage temp. Inert atmosphere,2-8°C
λmax 240nm(lit.)
Tiotropium bromide Uses

Tiotropium bromide is an organic bromide salt having (1alpha,2beta,4beta,5alpha,7beta)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[,4)]nonane as the counterion. Used (in the form of the hydrate) for maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease. It has a role as a bronchodilator agent and a muscarinic antagonist. It is an organic bromide salt and a quaternary ammonium salt.

Tiotropium is the dithienyl derivative of N-methyl scopolamine, a quaternary analogue of naturally occurring scopolamine in Atropa belladonna. It is indicated primarily for the relief of bronchospasms associated with COPD and can be considered to be a site-specific, local medication to the lung.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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