Why Urolithin A added to Dietary Supplements

As more clinical studies continue to demonstrate the wide-ranging benefits of Urolithin A, its presence in dietary supplements is expected to grow. Urolithin A has particularly for mitochondrial health, anti-aging, muscle function, and overall vitality. As a Urolithin A supplier, we provide a high-quality, bioavailable form of this compound that can help you enhance your product offerings, whether you’re in the fields of dietary supplements or pharmaceutical. But what exactly is Urolithin A, and why is it becoming a key ingredient in dietary supplements? The following blog will go into more depth about why Urolithin A is included in dietary supplements.

What is Urolithin A

Maxmedchem factory using fermentation for the biosynthesis of urolithin A involves selecting or engineering microorganisms capable of converting ellagic acid or ellagitannins into urolithin A. This is followed by optimizing fermentation conditions (temperature, pH, aeration, nutrients) for maximum yield. After fermentation, the UA is extracted, purified, and formulated for use in various industries such as nutraceuticals, pharmaceuticals, or cosmetics.

Bioavailability and Absorption of Urolithin A

Health Benefits: Despite its low bioavailability, urolithin A’s bioactive effects are significant. Its ability to stimulate mitophagy (the selective autophagic degradation of damaged mitochondria) and improve mitochondrial function has been linked to anti-aging effects, particularly in skeletal muscle and brain tissue. It has also demonstrated potential benefits in protecting against neurodegenerative diseases, improving physical performance, and enhancing cellular health.
Supplementation: Because of the variability in microbial ability to produce urolithin A from dietary sources, supplementation with pre-formed urolithin A (as opposed to relying on gut conversion) has been explored in clinical settings. This approach ensures more consistent and predictable bioavailability across individuals.
Pharmacokinetics in Humans: Studies on the pharmacokinetics of urolithin A have shown that its bioavailability is limited, but it may still be effective at the tissue level due to its potent biological activities at low concentrations. Research is ongoing to explore the potential for enhancing its absorption and effectiveness through novel drug formulations or delivery systems.

How Factory Produces Urolithin A?

As a Urolithin A factory, we produce urolithin A through a precise synthetic biofermentation process. We begin by sourcing high-quality polyphenols, such as ellagic acid, from natural sources like pomegranates. These compounds are then fermented using specialized probiotic strains that convert them into urolithin A. After fermentation, we purify and extract the compound using advanced filtration techniques to ensure the highest quality and potency. Throughout the entire process, we maintain strict quality control to guarantee that you receive a pure, reliable product that meets the highest standards.

1. Raw Material Sourcing: First, we source polyphenolic compounds, particularly ellagic acid, which are naturally present in fruits like pomegranates, berries, and walnuts. These compounds are essential as the starting point for urolithin A production. You’ll be pleased to know that we prioritize sustainably sourced materials to ensure quality and environmental responsibility.

2.Microbial Transformation: Once we have the raw materials, the next step involves microbial fermentation. We use specific strains of gut bacteria—known for their ability to break down ellagic acid—under controlled conditions. These microbes metabolize ellagic acid and other polyphenolic compounds into intermediate metabolites. Urolithin A is one of the key metabolites that results from this transformation.

3.Fermentation Process: The fermentation process takes place in bioreactors where temperature, pH, and oxygen levels are carefully monitored to optimize the growth of the beneficial bacteria and maximize the production of urolithin A. The microbial cultures are fed with the raw materials, and over several days, they convert the polyphenols into urolithin A.

4.Purification and Extraction: After fermentation, the resulting mixture contains UA along with other by-products. We use advanced filtration and purification methods, such as liquid chromatography, to isolate pure urolithin A. This step ensures that we provide you with a high-quality, concentrated product that meets the required purity standards.

5.Quality Control and Testing: We subject every batch of urolithin A to rigorous quality control tests to ensure it meets the necessary specifications for purity, potency, and safety. You can trust that every batch is thoroughly tested for consistency, so you get the same high-quality product every time.

Who Can Take Urolithin A?

Urolithin A can be beneficial for a wide range of individuals, particularly:

Healthy adults seeking to improve mitochondrial health, anti-aging, and muscle performance.
Older adults experiencing age-related muscle decline (sarcopenia) or cognitive issues.
Athletes and physically active individuals looking to enhance endurance, recovery, and muscle function.
People with mitochondrial dysfunction or those with neurodegenerative diseases (under medical supervision).

When to Take: Morning or Night?

I recommend taking urolithin A in the morning with your first meal, as it can help support energy levels and promote mitochondrial health throughout the day. However, if you prefer, you can also take it in the evening to support recovery and cellular regeneration while you sleep. The key is consistency, so choose the time that best fits your routine for optimal results. Just be sure to take it with food to improve absorption.

Dosage of Urolithin A

Typical Urolithin A Dosage Ranges

The most commonly studied and available dosages for urolithin A supplementation in clinical trials and products range from 250 mg to 1,000 mg per day.

1. Clinical Trial Evidence

Several clinical studies have explored the effects of urolithin A supplementation, particularly on muscle function, mitochondrial health, and aging. Here are some typical dosages from these studies:

250 mg to 500 mg per day: This dosage has been used in various human clinical studies. For instance, the Elysium Basis supplement, which combines urolithin A with nicotinamide riboside (NR), uses a 500 mg dose of urolithin A daily as part of its formulation.
1,000 mg per day: Some studies exploring the potential benefits of urolithin A for muscle health and aging have used 1,000 mg as the upper dose. Research indicates that this higher dosage is well-tolerated, with promising results in improving muscle endurance, reducing fatigue, and enhancing overall vitality.

2. Supplementation in Healthy Adults

Common Dosage Range: 500 mg to 1,000 mg per day is typically recommended for most adults, based on the available clinical evidence for its effects on muscle strength, cognitive function, and mitochondrial health.
Elysium Basis Supplement: Elysium Health markets a combination product (Basis) containing 500 mg of UA per day in combination with nicotinamide riboside (NR), a precursor to NAD+ (nicotinamide adenine dinucleotide), which is another compound believed to support mitochondrial function and longevity.

3. Specific Conditions (e.g., Aging, Mitochondrial Health, and Sarcopenia)

For Aging and Longevity: The 500 mg to 1,000 mg dosage range is commonly recommended to support mitochondrial function, combat the effects of aging, and enhance general health.
For Muscle Function: For individuals experiencing age-related muscle decline (sarcopenia), a dose in the range of 500 mg to 1,000 mg per day may be used to help improve muscle strength, endurance, and recovery. Some studies have suggested benefits for individuals aged 65+ in this dosage range.
For Cognitive Function: Urolithin A’s potential neuroprotective effects may benefit cognitive health, though more research is needed. For such purposes, starting with 500 mg per day is a reasonable option.

4. Duration of Use

Urolithin A supplementation in clinical studies generally lasts for 3–12 weeks, with benefits often becoming noticeable after several weeks of consistent use. For long-term use, it is important to follow the dosage guidelines provided by the product manufacturer or a healthcare provider.

Safety of Urolithin A

1. Human Clinical Studies and Tolerability

Well-Tolerated in Clinical Trials: In the available clinical trials, urolithin A has been generally well-tolerated in humans, with no significant adverse effects reported at common dosages (ranging from 250 mg to 1,000 mg per day). Studies investigating its effects on aging, muscle function, and mitochondrial health have primarily observed mild to no side effects.
Elysium Basis: One of the most well-known urolithin A-containing products is Elysium Basis, which combines UA with nicotinamide riboside (NR), a precursor of NAD+. The urolithin A dosage in Basis is 500 mg per day, and no serious adverse events have been reported in clinical trials or from consumer use at this dosage.

2. Mild Side Effects

Gastrointestinal Discomfort: Like many supplements, some individuals may experience mild digestive side effects when starting urolithin A supplementation. These can include bloating, gas, or mild stomach discomfort. These side effects tend to be temporary and usually resolve after a few days of use.
No Serious Adverse Events: Clinical studies have not reported any serious or severe adverse reactions, and long-term safety has not raised significant concerns. However, as with any supplement, individual responses may vary.

3. Long-Term Safety

Limited Long-Term Data: While urolithin A has shown promising results in clinical studies lasting up to 12 weeks, the long-term safety (beyond 6–12 months of continuous use) is still not fully established. Research is ongoing to evaluate the potential long-term effects of regular urolithin A supplementation.
Potential Risks of Excessive Dosage: Although no serious adverse effects have been identified at typical dosages (250 mg–1,000 mg daily), consuming significantly higher doses could theoretically lead to unanticipated side effects. However, no reports indicate that this is a concern at the standard supplementation doses.

4. Allergic Reactions

Rare Allergic Responses: As with any bioactive supplement, there is a small potential for allergic reactions. Individuals with known allergies to pomegranate or other polyphenol-rich foods may want to exercise caution when taking urolithin A, as it is derived from such compounds. Symptoms of an allergic reaction could include rash, swelling, or difficulty breathing. If such symptoms occur, discontinuing the supplement and seeking medical attention is recommended.

5. Interactions with Medications

Potential Drug Interactions: Urolithin A is generally regarded as safe, but its interaction with certain medications has not been extensively studied. Some compounds that promote mitochondrial function or influence cellular metabolism may interact with medications that affect similar pathways. Therefore, individuals taking medications for metabolic conditions, diabetes, blood pressure, or cardiovascular diseases should consult with a healthcare provider before starting supplementation.
Blood Thinning and Antioxidants: UA, due to its antioxidant properties, could potentially interact with medications that affect oxidative stress or blood-thinning (e.g., warfarin or aspirin). Although there is no direct evidence to suggest significant interactions, it’s wise for individuals taking such medications to discuss urolithin A use with their doctor.

Price of Urolithin A Supplements

The price of Urolithin A supplements can vary significantly depending on factors such as the brand, the dose per serving, the formulation (e.g., capsules, powders), and the quantity per bottle or package. Additionally, prices may differ based on the region and distribution channels (e.g., direct from Maxmedchem manufacturers, online retailers, or physical stores).

Here’s an overview of the general price range for Urolithin A supplements based on common options available in the market:

Brand/Product	Price (30-Day Supply)	Dose Per Serving	Form
Elysium Basis	$60–$70	500 mg	Capsules (2/day)
Timeline Cell+	$50–$60	500 mg	Capsules (2/day)
Juvenon Urolithin A	$30–$40	250 mg	Capsules (1/day)
Pure Encapsulations	$40–$60	250–500 mg	Capsules (1–2/day)
Essence medchem Co., Ltd (Raw Powder)	$400–$500	1-25KG (Bulk)	Powder

Does Combining Urolithin A with Other Products?

1. Urolithin A + Nicotinamide Riboside (NR)

Why Combine: Both Urolithin A and Nicotinamide Riboside (NR) support mitochondrial function, but through different mechanisms. While Urolithin A promotes mitophagy (the removal of damaged mitochondria) and mitochondrial biogenesis (creation of new mitochondria), NR is a precursor of NAD+ (Nicotinamide Adenine Dinucleotide), which is crucial for energy production and mitochondrial function at the cellular level. NR helps to increase NAD+ levels, which naturally decline with age.
Synergistic Effect: Combining UA with NR could potentially enhance overall cellular energy production and mitochondrial health. NAD+ is necessary for many cellular functions, and its increased levels could further optimize the benefits of Urolithin A’s effects on mitochondrial turnover and cellular repair.

2. Urolithin A + Resveratrol

Why Combine: Resveratrol is a polyphenol found in grapes and red wine, known for its antioxidant and anti-inflammatory effects. It is often associated with the activation of sirtuins, proteins that are linked to longevity and metabolic health. Resveratrol is believed to mimic some aspects of caloric restriction, a process linked to increased lifespan.
Synergistic Effect: Combining Urolithin A (which enhances mitochondrial health) with Resveratrol (which activates sirtuins and promotes cellular repair) could work well for promoting healthy aging, energy, and longevity. This combination may enhance mitochondrial function and improve the body’s ability to deal with oxidative stress and inflammation.

3.Urolithin A + Coenzyme Q10 (CoQ10)

Why Combine: Coenzyme Q10 is a potent antioxidant that plays a crucial role in energy production within mitochondria. CoQ10 is often used to support heart health, exercise performance, and mitochondrial function. While Urolithin A helps to cleanse and regenerate mitochondria, CoQ10 supports mitochondrial efficiency and energy output.
Synergistic Effect: Combining Urolithin A with CoQ10 could potentially improve mitochondrial function on multiple levels, enhancing both the quality and quantity of mitochondria. CoQ10 can help ensure that the mitochondria that are retained after mitophagy are functioning at optimal capacity, while Urolithin A can enhance the overall health of the mitochondria.

4.Urolithin A + Pterostilbene

Why Combine: Pterostilbene is a compound closely related to resveratrol, found in blueberries and known for its antioxidant, anti-inflammatory, and anti-aging It has been shown to support brain health, cognitive function, and cardiovascular health.
Synergistic Effect: Combining Urolithin A with Pterostilbene can provide a dual effect: while Urolithin A promotes mitochondrial health and muscle function, Pterostilbene may help protect against oxidative stress and inflammation in the brain and cardiovascular system. This could enhance both cognitive health and overall longevity.

5.Urolithin A + Curcumin

Why Combine: Curcumin, the active compound in turmeric, is widely recognized for its anti-inflammatory, antioxidant, and anti-cancer It has also been shown to have a positive impact on brain health and joint health. As a potent anti-inflammatory compound, curcumin can help reduce the inflammation that often accompanies aging.
Synergistic Effect: Combining Urolithin A with Curcumin could provide comprehensive benefits for aging and overall wellness. While Urolithin A supports mitochondrial health and reduces mitochondrial dysfunction, Curcumin can reduce systemic inflammation, supporting cognitive health and joint function.

6.Urolithin A + Omega-3 Fatty Acids (EPA/DHA)

Why Combine: Omega-3 fatty acids, particularly EPA and DHA, are essential for brain health, cardiovascular health, and anti-inflammatory responses. These fatty acids help support membrane integrity and cellular communication, which can be vital for maintaining healthy cellular function as we age.
Synergistic Effect: Combining UA with Omega-3s could support brain function and heart health while promoting mitochondrial health and cellular rejuvenation. Omega-3s can help to reduce systemic inflammation and support cognitive function, which may complement Urolithin A’s benefits on energy and muscle function.

7.Urolithin A + Adaptogens (Ashwagandha, Rhodiola)

Why Combine: Adaptogens like Ashwagandha and Rhodiola are known for their ability to help the body adapt to stress, improve energy, and balance hormones. These herbs can also promote mental clarity, reduce fatigue, and enhance physical endurance.
Synergistic Effect: Urolithin A enhances mitochondrial function, while adaptogens can help combat stress and improve overall physical performance. Together, they may help improve mental clarity, muscle function, and resilience to stress.

Conclusion

Looking for an support mitochondrial function, longevity, anti-aging, and energy production? Look no further than raw supplement ingredients suppliers! If you need wholesale Urolithin A Powder or need COA support, Please Contact us!