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Zileuton(111406-87-2)C11H12N2O2S

  • Chemical Name: Zileuton
  • CAS No.:111406-87-2
  • MF:C11H12N2O2S
  • MW:236.29
  • Purity:≥98% or according to customer requested
  • Color: White to off-white
  • Product Categories:;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Active Pharmaceutical Ingredients;
  • Test method: HPLC
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What is Zileuton?

Zileuton is a member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma. It has a role as an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor, a non-steroidal anti-inflammatory drug, an anti-asthmatic drug, a leukotriene antagonist and a ferroptosis inhibitor. It is a member of ureas and a member of 1-benzothiophenes. It derives from a hydride of a 1-benzothiophene. (Source: ChEBI)

Introduction    
Product Name: Zileuton
Synonyms: Leutrol; Zileutonum; Ziluton
CAS: 111406-87-2
MF: C11H12N2O2S
MW: 236.29
EINECS: 601-087-3
Product Categories: Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; Active Pharmaceutical Ingredients; Respiratory Drugs
Chemical Structure

Zileuton            

Chemical Properties
           
Melting point  157-158°C
Boiling point  449.4±47.0 °C(Predicted)
density  1.401±0.06 g/cm3(Predicted)
storage temp.  room temp
solubility  DMSO: ≥20mg/mL at ~60°C (warm up to 60 C for 5min)
pka pKa 10.3(H2O t undefined I undefined) (Uncertain)
form  powder
color  white to off-white
Zileuton Uses And Synthesis

Zileuton, a benzothiophene N-hydroxyurea, is the only approved inhibitor of 5-lipoxygenase. It is believed to intervene with allergic and inflammatory diseases by suppression of leukotriene (LT) biosynthesis. The compound belongs to the class of iron ligand-type inhibitors of 5-lipoxygenase that not only chelates the active site iron of the enzyme but also possesses weak-reducing properties.

Maxmedchem, a global supplier of Zileuton, 111406-87-2 offers for your requirements of RND / Development quantities or commercials, based on status of the product. We can also offer other intermediates with supportive technical package required for evaluation.

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

Email us at: info@maxmedchem.com for more details.       

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