Spermidine Trihydrochloride VS Spermidine

Spermine and spermidine trihydrochloride as active ingredients in the preparation of a composition for dietary, pharmaceutical or cosmetic use in humans for health and beauty of the skin and skin appendages, and related compositions for pharmaceutical or dietary or cosmetic use for administration to humans.

What is Spermidine

Spermidine was first discovered in 1678 by Dutch scientist Anton Van Leeuwenhoek in a sample of human semen. Shortly after, spermidine was discovered in human sperm. In the body, spermidine is created from its precursor, putrescine. It is the precursor for another polyamine called spermine, which is also important for cellular function.

What is the best source of Spermidine

The food categories with the highest contents of spermidine and spermine are cereals, legumes and soy derivatives. Wheat germ and soybeans stand out in particular, with respective values of 2,437 and 1,425 nmol/g for spermidine and 722 nmol/g and 341 nmol/g for spermine.

What is Wheat Germ Extract 1%

Wheat germ extract contains the largest amounts of Spermidine, it is 1% spermidine contain. The Spermidine in wheat germ is useful in slowing cancer growth and enhances cardiovascular health. It also contains antioxidants and can improve your overall immunity.

Spermidine forms and specifications

Other terms referring to spermidine are spermidine trihydrochloride powder, Wheat Germ Extract Powder (Spermidine) 1%.

What is the purpose of Spermidine

Spermidine, a natural polyamine, plays a critical role in molecular and cellular interactions involved in various physiological and functional processes. Spermidine has been shown to modulate aging, suppress the occurrence and severity of age-related diseases, and prolong lifespan.

Spermidine benefits

Spermidine displays pleiotropic effects that include anti-inflammatory properties, antioxidant functions, enhancement of mitochondrial metabolic function and respiration, as well as improved proteostasis and chaperone activity, including：

1. Spermidine anti-aging
Cell aging occurs when the natural process of autophagy, which is the recycling of damaged cells, goes wrong. Spermidine, as an autophagy modulator, can be an effective weapon against aging. Spermidine concentration decreases with age. Taking spermidine supplement powder is associated with aging and reduces the number of free radicals.

2. Spermidine and Hair growth
Research has shown that using spermidine supplements can promote hair growth. For example, a study of 100 healthy people showed that a spermidine-based dietary supplement prolongs the phase of active hair growth, called the anagen phase. The longer the hair follicle remains in the anagen phase, the longer the hair will grow. Research in test tubes has also shown that spermidine stimulates human hair growth.

3. Spermidine improves Cardiovascular Health
Spermidine from food sources has been shown to bring out cardioprotective effects through autophagy, according to studies in rats, mice, and humans demonstrating reduced hypertension and arterial aging. Similarly, increased spermidine intake is associated with reduced blood pressure and lower risk of cardiovascular disease, leading to lower mortality in humans.

4. Spermidine benefits to prevents Cancer
In addition to increasing lifespan, up to 25%, research conducted in mice has shown that spermidine supplementation decreases liver fibrosis and cancer risk, even in subjects exposed to chemicals inducing liver fibrosis. Human observational studies also link the intake of dietary spermidine with decreased risk of colon cancer. When you take Spermidine supplements made with spermidine trihydrochloride powder, you will go a long way in protecting your body from cancer. You can use Spermidine supplements during cancer treatment.

5. Spermidine may reduce cognitive decline
Research published in 2021 in the journal Cell Reports provides a detailed account of dietary spermidine improving cognition and mitochondrial function in flies and mice, with some prospective human data to top it off. While this study was interesting, it had some limitations, and additional dose-response data is needed before a firm conclusion can be made about benefits to human cognition. Taking spermidine supplement powder may can reverse neuron damages caused by inflammation, oxidative stress, and ischemia.It may can decrease the risk of suffering neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.

6. Spermidine and Weight Loss
While spermidine seems to play a role in the formation of fat cells, there is no evidence foods (or supplements) containing this substance promotes weight loss. Likewise, nobody can say if this stuff boosts metabolism either. Human research on weight loss and metabolic rate is lacking.

Spermidine vs NMN

They both are hot ingredients for anti-aging and longevity, but the mechanism of action is different. spermidine ingredients help against aging through autophagy, while NMN Powder can have beneficial effects in anti-aging by boosting the NAD+ levels in our body. Spermidine supplementation is a better way to accomplish your goals because autophagy is a natural process that begins to break down and recycle damaged cells. They are both soluble and stable in water, with high bioavailability.

Spermidine vs Spermine

Spermine is another type of polyamine. Both compounds are related to each other. Spermine is derived from Spermidine and is crucial for cell metabolism in human beings and plants. Taking spermidine supplements made with spermidine trihydrochloride powder ensures that you get spermine benefits too.

Is Spermidine safe

Spermidine is a naturally occurring product in the body and part of the natural diet. The data suggests that spermidine supplementation using a spermidine supplement is safe and well-tolerated.

Spermidine dosage

The optimal spermidine dosage has not been established, although some experiments in older adults show that 1.2 mg of spermidine per day is completely safe.

Spermidine side effects

No side effects are observed while taking spermidine supplement powder, if you do experience Spermidine side effects, cease taking it immediately and consult your doctor. To buy best spermidine will help to avoid the bad side effects.

What is the difference between Spermidine and Spermidine Trihydrochloride?

Spermidine vs spermidine trihydrochloride:
Spermidine base is in liquid form, while Spermidine trihydrochloride is in powder form. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive. Spermidine trihydrochloride powder benfits are the same with Spermidine benefits.

What is Spermidine Trihydrochloride Powder？

Spermidine trihydrochloride powder, it is the trihydrochloride form of spermidine. Spermidine trihydrochloride powder is a synthetic chemical compound soluble in water. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive. Spermidine trihydrochloride powder benfits are the same with Spermidine benefits.

What is the formula for Spermidine Trihydrochloride?

Spermidine trihydrochloride | C7H22Cl3N3 | CID 9539 – Maxmedchem

Spermidine Trihydrochloride forms and specifications

Spermidine trihydrochloride powder 98% is white fine powder, and made by synthetic process.

The advantage of spermidine trihydrochloride supplements is that they contain a controlled amount of the active ingredient. Natural resources, on the other hand, are subject to great natural variability. Therefore, high quality Spermidine trihydrochloride powder 98% is your best choice.

Spermidine Trihydrochloride benefits

In addition to promoting autophagy, spermidine trihydrochloride has been shown to have anti-inflammatory and antioxidant properties. Chronic inflammation and oxidative stress are major causes of aging and age-related diseases, and spermidine trihydrochloride is able to mitigate these processes, making it a promising candidate for promoting longevity and overall health. additionally, Spermidine trihydrochloride powder has been shown to lower blood pressure, improve blood flow, and prevent heart disease. These cardiovascular benefits further enhance its potential to promote longevity and overall health.

Spermidine Trihydrochloride Supplements: How to Choose the Right One for You

1. Purity and Quality
Purity and quality are crucial when choosing a spermidine trihydrochloride supplement. Look for supplements made by reputable factories, using high-quality ingredients and strict quality control measures. It is also important to ensure that the supplement has been independently tested by a third-party organization to verify its purity and potency.

2. Bioavailability
Bioavailability refers to the body’s ability to absorb and utilize a specific nutrient. When choosing a spermidine trihydrochloride supplement, you must consider its bioavailability.

3. Dosage and concentration
The dosage and concentration of spermidine trihydrochloride in supplements can vary widely between products. It is crucial to choose a supplement that provides an optimal dose of spermidine and is consistent with the latest scientific research on its potential benefits. Additionally, consider your personal needs and health goals when choosing a supplement containing the appropriate concentration of spermidine.

4. Formulation and additional ingredients
In addition to spermidine trihydrochloride, many supplements contain other ingredients that enhance their effectiveness or provide complementary health benefits. Consider whether you would prefer a stand-alone spermidine supplement or a formula containing other nutrients such as vitamins, minerals, or antioxidants. Be aware of any potential allergens or additives in supplement formulas.

5. Research and Transparency
When considering a spermidine trihydrochloride supplement, look for brands that are transparent about their sourcing, manufacturing processes, and the scientific research that supports their products. Reputable manufacturers often provide detailed information about the origins of their ingredients, the production methods used, and the evidence-based benefits of their supplements.

What is the best form of Spermidine Trihydrochloride to take?

Common spermidine supplement is synthetic spermidine. This form of spermidine is produced through chemical synthesis, and while it can provide a concentrated source of the compound. And spermidine trihydrochloride has attracted a lot of attention in the health and wellness community for its potential anti-aging and health benefits. There are several forms of spermidine trihydrochloride on the market, each with its own advantages and disadvantages.

1. Capsules
One of the most popular forms of spermidine trihydrochloride is capsule form. This is a convenient option for those who like to take their supplements quickly and easily. Capsules are also a good option for people who have difficulty swallowing tablets or who want to avoid the bitter taste of spermidine trihydrochloride in its original form. When choosing spermidine trihydrochloride capsules, it is important to look for a brand that uses high-quality ingredients and has a proven track record. You should also consider the dosage and make sure it meets your personal needs and health goals.

2. Powder
Spermidine trihydrochloride is also available in powder form that can be mixed into liquids or foods for easy consumption. This form is especially convenient for people who have difficulty swallowing pills or who prefer to tailor their dosage to their specific needs. When considering spermidine trihydrochloride powder, it is important to choose a high-quality product that is free of additives and fillers.

Conclusion

Unfortunately, our body accumulates damage as we age, increasing our propensity for disease. Likewise, our natural spermidine levels gradually decline with age. However, this can be rectified by eating foods high in spermidine and taking Spermidine supplements, thus limiting the impact of aging on longevity. While it is generally beneficial to enjoy a varied diet rich in whole foods, the most effective way to attenuate declining spermidine levels is by taking spermidine trihydrochloride powder. Although not monitored by the FDA with the same regularity as pharmaceutical drugs, longevity supplements commonly contain ingredients found naturally in the body and food, so pair high efficacy with low toxicity. Spermidine supplements are available in powder or tablet form and when taken regularly can effectively delay age. A hot topic on the longevity supplement scene, there are several competing brands of spermidine supplements that are all marketed as having anti-aging benefits. Designed to be taken daily to support a healthy lifestyle, the supplements can also be combined with other longevity ingredients like Resveratrol Powder. The best Spermidine supplements is the one made with spermidine trihydrochloride powder. Spermidine trihydrochloride powder is more stable form, always buy spermidine trihydrochloride powder from the real suppliers.

Where to buy Spermidine Trihydrochloride Powder?

You will mostly find wheat germ extract spermidine powder capsules when you try to search spermidine supplements -but these are generally underdosed. Most don’t even list how much spermidine they have. Maxmedchem offers bulk spermidine trihydrochloride powder. The best spermidine supplement powder is with high purity and bioavailability.

Our company as a manufacturers factory offers large stock and wholesale pricing about spermidine trihydrochloride powder and Spermidine.✨Want to try a sample? Request one here.

FAQs:

Q: What is Spermidine Trihydrochloride?
Spermidine Trihydrochloride is a natural polyamine compound found in various foods such as wheat germ, soybeans, and mushrooms. It has been studied for its potential health benefits in supporting cellular health and promoting longevity.

Q: How do I choose the best Spermidine Trihydrochloride supplement?
When choosing a Spermidine Trihydrochloride supplement, it is important to look for a reputable brand that uses high-quality ingredients and has been tested for purity and potency. It is also recommended to consult with a healthcare professional before starting any new supplement regimen.

Q: What are the potential benefits of taking Spermidine Trihydrochloride supplements?
Spermidine Trihydrochloride supplements have been studied for their potential benefits in supporting cellular health, promoting autophagy (the body’s natural process of cellular waste removal), and potentially extending lifespan. However, more research is needed to fully understand the long-term benefits and potential risks of Spermidine Trihydrochloride supplementation.

Q: ls Spermidine the same as wheat germ?
Spermidine is found in many of the foods that we eat. And in fact, our Wheat Germ Extract Powder (Spermidine) 1% are extracted from wheat germ. However, we often don’t get what we need from diet alone, especially as we age and our body needs more nutrients. This is where supplements can step in to help support a healthy body.

Q: Can l take Spermidine on an empty stomach?
In any case, we recommend to take the Spermidine during a meal to increase bioavailability.

Q: when should l take Spermidine supplements?
Some experiments showed that 1.2 mg of spermidine per day is completely safe. Whether this is done in the morning, at noon or in the evening, is subject to your personal preferences, but we recommend taking it always at the same time of the day.

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References

[1] Kishi et al (1998) Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats. Brain Res. 793 311 PMID: 9630697

[2] Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA <em>in vivo</em>. Brain Res. 616 163 PMID: 8358608

[3] Deeb, F., van der Weele, C. M., & Wolniak, S. M. (2010). Spermidine is a morphogenetic determinant for cell fate specification in the male gametophyte of the water fern Marsilea vestita. The Plant Cell, 22(11), 3678-3691.

[4] Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., … & Fussi, H. (2009). Induction of autophagy by spermidine promotes longevity. Nature cell biology, 11(11), 1305-1314.

[5] Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., … & Fussi, H. (2009). Induction of autophagy by spermidine promotes longevity. Nature cell biology, 11(11), 1305-1314.

[6] Williams et al (1989) Effects of polyamines on the binding of [³H]-MK801 to the N-MthD.-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site. Mol.Pharmacol. 36 375 PMID: 2554112

[7] Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1530929

[8] Ghada Alsaleh Is a corresponding author, Isabel Panse, Leo Swadling, Hanlin Zhang, Felix Clemens Richter, Alain Meyer, Janet Lord, Eleanor Barnes, Paul Klenerman, Christopher Green, Anna Katharina Simon. “Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses” Dec 15, 2020.

[9]Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics.

Nils C. Gassen, Jan Papies, Thomas Bajaj, Frederik Dethloff, Jackson Emanuel, Katja Weckmann, Daniel E. Heinz, Nicolas Heinemann, Martina Lennarz, Anja Richter, Daniela Niemeyer, Victor M. Corman, Patrick Giavalisco, Christian Drosten, Marcel A. Müller. doi: 10.1038/s41467-021-24007-w

[10] Goldman, S. J., Taylor, R., Zhang, Y., & Jin, S. (2010). Autophagy and the degradation of mitochondria. Mitochondrion, 10(4), 309-315.

[11]Minois, N., Carmona-Gutierrez, D., & Madeo, F. (2011). Polyamines in aging and disease. Aging (Albany NY), 3(8), 716-732.

[12] Nelly C. Muñoz-Esparza, M. Luz Latorre-Moratalla, Oriol Comas-Basté, Natalia Toro-Funes, M. Teresa Veciana-Nogués, and M. Carmen Vidal-Carou. “Polyamines in Food” Front Nutr. 2019; 6: 108. Published online 2019 Jul 11. doi: 10.3389/fnut.2019.00108. PMC6637774

[13] Schroeder, S., Hofer, S.J., Zimmermann, A., Pechlaner, R., Dammbrueck, C., … & Madeo, F. (2021). Dietary spermidine improves cognitive function. Cell Reports, 35(2), 108985. https://doi.org/10.1016/j.celrep.2021.108985